VEZF1
Vascular Endothelial Zinc Finger 1
Gene Information Card
| Symbol | VEZF1 |
|---|---|
| Full Name | Vascular Endothelial Zinc Finger 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q22 |
| NCBI Gene ID | 7716 ncbi.nlm.nih.gov/gene/7716 |
| Ensembl ID | ENSG00000108379 |
| UniProt ID | Q9H9V9 |
| OMIM ID | 606262 |
| HGNC ID | 12687 |
| Aliases | DB1, ZNF161, ZFP161 |
Description
VEZF1 (Vascular Endothelial Zinc Finger 1) is a protein-coding gene that encodes a zinc finger transcription factor. It is involved in the regulation of gene expression, particularly in endothelial cells, and plays a role in vascular development and function. The protein binds to specific DNA sequences to modulate transcription.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | Not available |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 10.2 | Medium |
| Lung | 8.5 | Medium |
| Liver | 6.1 | Low |
| Kidney | 7.8 | Medium |
| Brain | 5.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC | 12.4 | Endothelial cell line |
| HEK 293 | 9.1 | Embryonic kidney |
| HeLa | 7.6 | Cervical cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic mutations reported in ClinVar | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
Not established
Gain of Function (GOF)
Not established
Dominant Negative (DN)
Not established
View complete mutation data：
Gene Ontology (GO)
| • DNA binding | • zinc ion binding |
| • transcription factor activity | • sequence-specific DNA binding |
| • regulation of transcription | • DNA-templated |
Pathways
• Not available
Protein Summary
The VEZF1 protein is a zinc finger transcription factor that localizes to the nucleus and binds to specific DNA sequences to regulate gene expression. It is implicated in endothelial cell function and vascular biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VEZF1 Knockout HEK293 Cell Line | EDJ-KQ6084 | Human | 7716 | Details Get a Quote |
| VEZF1 Knockout A-549 Cell Line | EDJ-KQ29797 | Human | 7716 | Details Get a Quote |
| VEZF1 Knockout HCT 116 Cell Line | EDJ-KQ29798 | Human | 7716 | Details Get a Quote |
| VEZF1 Knockout HeLa Cell Line | EDJ-KQ29799 | Human | 7716 | Details Get a Quote |
