VCX3B
Variable Charge X-linked 3B
Gene Information Card
| Symbol | VCX3B |
|---|---|
| Full Name | Variable Charge X-linked 3B |
| Gene Type | Protein coding |
| Chromosomal Location | Xp22.31 |
| NCBI Gene ID | 100101267 ncbi.nlm.nih.gov/gene/100101267 |
| Ensembl ID | ENSG00000215262 |
| UniProt ID | Q8N7H5 |
| OMIM ID | 300532 |
| HGNC ID | 37299 |
| Aliases | VCX-3B, VCX3, VCX3B1 |
Description
VCX3B is a member of the variable charge X-linked (VCX) gene family located on chromosome Xp22.31. The gene encodes a small protein of unknown function, characterized by a high content of charged amino acids. VCX3B is expressed predominantly in testis and brain, and its expression is regulated by the VCX gene cluster. No specific disease associations have been established to date.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No known disease associations | Not applicable | No evidence in OMIM, ClinVar, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 3.2 | Low |
| Lung | 0.8 | Not detected |
| Liver | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 2.1 | Low expression |
| K562 | 1.0 | Low expression |
| HeLa | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The VCX3B protein (UniProt Q8N7H5) is a small, highly charged protein of 108 amino acids. Its function remains uncharacterized, but it is predicted to be involved in cellular processes related to charge-mediated interactions. No structural or functional domains have been annotated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VCX3B Knockout HEK293 Cell Line | EDJ-KQ16095 | Human | 425054 | Details Get a Quote |
| VCX3B Knockout HeLa Cell Line | EDJ-KQ60368 | Human | 425054 | Details Get a Quote |
| VCX3B Knockout A-549 Cell Line | EDJ-KQ68836 | Human | 425054 | Details Get a Quote |
| VCX3B Knockout HCT 116 Cell Line | EDJ-KQ77199 | Human | 425054 | Details Get a Quote |
