VAMP3: Vesicle Associated Membrane Protein 3
A key SNARE protein in vesicular transport and membrane fusion
Gene Information Card
| Symbol | VAMP3 |
|---|---|
| Full Name | Vesicle Associated Membrane Protein 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.23 |
| NCBI Gene ID | 9341 ncbi.nlm.nih.gov/gene/9341 |
| Ensembl ID | ENSG00000117569 |
| UniProt ID | Q15836 |
| OMIM ID | 603657 |
| HGNC ID | 12644 |
| Aliases | CEB, VAMP-3, cellubrevin |
Description
VAMP3 (Vesicle Associated Membrane Protein 3), also known as cellubrevin, is a member of the SNARE protein family. It is involved in vesicular transport and membrane fusion, particularly in recycling endosomes and exocytosis. VAMP3 mediates the docking and fusion of vesicles with target membranes, playing a role in processes such as neurotransmitter release, glucose transporter translocation, and immune cell degranulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Infectious diseases (e.g., bacterial toxin entry) | VAMP3 is cleaved by tetanus and botulinum neurotoxins, impairing vesicle fusion and neurotransmitter release. | PMID: 10611321 |
| Cancer (e.g., breast cancer) | Altered VAMP3 expression may affect exocytosis and cell signaling, contributing to tumor progression. | COSMIC: VAMP3 mutations in various cancers |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 10.2 | Medium |
| Testis | 15.7 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.3 | Ubiquitous expression |
| HEK293 | 11.8 | Moderate expression |
| A549 | 9.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon, likely loss of function |
| c.100C>T (p.Arg34Trp) | missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Cleavage by bacterial toxins (e.g., tetanus toxin) leads to loss of VAMP3 function, inhibiting vesicle fusion.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • SNAP receptor activity (GO:0005484) | • intracellular protein transport (GO:0006886) |
| • vesicle fusion (GO:0006906) | • membrane (GO:0016020) |
| • SNARE complex (GO:0031201) |
Pathways
• SNARE interactions in vesicular transport (KEGG: hsa04130)
• Membrane trafficking (Reactome: R-HSA-199991)
Protein Summary
VAMP3 is a small integral membrane protein (approximately 12 kDa) that localizes to recycling endosomes and plasma membrane. It forms SNARE complexes with syntaxin 4 and SNAP23 to mediate vesicle fusion. VAMP3 is ubiquitously expressed and is a target for clostridial neurotoxins, which cleave it to block exocytosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| VAMP3 Knockout HEK293 Cell Line | EDJ-KQ6554 | Human | 9341 | Details Get a Quote |
| VAMP3 Knockout HCT 116 Cell Line | EDJ-KQ29402 | Human | 9341 | Details Get a Quote |
| VAMP3 Knockout A-549 Cell Line | EDJ-KQ30753 | Human | 9341 | Details Get a Quote |
| VAMP3 Knockout HeLa Cell Line | EDJ-KQ30755 | Human | 9341 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
