USP2: Ubiquitin Specific Peptidase 2
A deubiquitinating enzyme involved in cell cycle regulation, apoptosis, and cancer.
Gene Information Card
| Symbol | USP2 |
|---|---|
| Full Name | Ubiquitin Specific Peptidase 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q23.3 |
| NCBI Gene ID | 9099 ncbi.nlm.nih.gov/gene/9099 |
| Ensembl ID | ENSG00000148840 |
| UniProt ID | O75604 |
| OMIM ID | 604725 |
| HGNC ID | 12618 |
| Aliases | UBP41, USP2-AS1 |
Description
USP2 (Ubiquitin Specific Peptidase 2) encodes a deubiquitinating enzyme that removes ubiquitin from target proteins, thereby regulating protein stability, cell cycle progression, and apoptosis. It is involved in the deubiquitination of MDM2, FAS, and other substrates, and has been implicated in various cancers and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | USP2 overexpression stabilizes MDM2, leading to p53 degradation and tumor progression. | PMID: 16959974 |
| Breast Cancer | USP2 deubiquitinates and stabilizes FAS, promoting cell survival. | PMID: 21502526 |
| Colorectal Cancer | USP2 upregulation correlates with poor prognosis and increased proliferation. | PMID: 23431179 |
| Obesity | USP2 regulates insulin signaling and adipogenesis via deubiquitination of IRS-1. | PMID: 23563491 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Prostate | 8.3 | Medium |
| Breast | 5.1 | Low |
| Colon | 4.7 | Low |
| Liver | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.2 | High expression |
| HeLa | 7.8 | Medium expression |
| MCF7 | 6.4 | Medium expression |
| LNCaP | 9.1 | High expression |
| HCT116 | 5.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.112G>A (p.Gly38Arg) | Missense | <0.01% | Unknown |
| c.457C>T (p.Arg153Trp) | Missense | <0.01% | Unknown |
| c.763_764insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.763_764insA) are predicted to cause loss of deubiquitinase activity.
Gain of Function (GOF)
Not well characterized; overexpression in cancer suggests potential gain-of-function via substrate stabilization.
Dominant Negative (DN)
No dominant negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cysteine-type deubiquitinase activity | • ubiquitin-specific protease activity |
| • protein deubiquitination | • proteasome-mediated ubiquitin-dependent protein catabolic process |
| • cell cycle | • apoptotic process |
Pathways
• p53 signaling pathway
• Ubiquitin mediated proteolysis
• Apoptosis
Protein Summary
USP2 is a 605-amino acid deubiquitinating enzyme containing a catalytic cysteine box and a ubiquitin-interacting motif. It cleaves ubiquitin from specific substrates, including MDM2, FAS, and IRS-1, thereby regulating protein stability and signaling. The protein is predominantly cytoplasmic and is highly expressed in testis and prostate.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| USP2 Knockout HEK293 Cell Line | EDJ-KQ1072 | Human | 9099 | Details Get a Quote |
| USP26 Knockout HEK293 Cell Line | EDJ-KQ2375 | Human | 83844 | Details Get a Quote |
| USP20 Knockout HEK293 Cell Line | EDJ-KQ2461 | Human | 10868 | Details Get a Quote |
| USP21 Knockout HEK293 Cell Line | EDJ-KQ2970 | Human | 27005 | Details Get a Quote |
| USP24 Knockout HEK293 Cell Line | EDJ-KQ7987 | Human | 23358 | Details Get a Quote |
| USP28 Knockout HEK293 Cell Line | EDJ-KQ12007 | Human | 57646 | Details Get a Quote |
| USP22 Knockout HEK293 Cell Line | EDJ-KQ16074 | Human | 23326 | Details Get a Quote |
| USP25 Knockout HEK293 Cell Line | EDJ-KQ16075 | Human | 29761 | Details Get a Quote |
| USP27X Knockout HEK293 Cell Line | EDJ-KQ16076 | Human | 389856 | Details Get a Quote |
| USP29 Knockout HEK293 Cell Line | EDJ-KQ16077 | Human | 57663 | Details Get a Quote |
| USP28 Knockout HCT 116 Cell Line | EDJ-KQ17922 | Human | 57646 | Details Get a Quote |
| USP25 Knockout HCT 116 Cell Line | EDJ-KQ18080 | Human | 29761 | Details Get a Quote |
| USP2 Knockout A-549 Cell Line | EDJ-KQ20206 | Human | 9099 | Details Get a Quote |
| USP2 Knockout HCT 116 Cell Line | EDJ-KQ20207 | Human | 9099 | Details Get a Quote |
| USP20 Knockout A-549 Cell Line | EDJ-KQ23007 | Human | 10868 | Details Get a Quote |
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