USP17L28 Gene - Ubiquitin Specific Peptidase 17 Like Family Member 28
A deubiquitinating enzyme gene with potential roles in cell proliferation and cancer, part of the USP17-like family.
Gene Information Card
| Symbol | USP17L28 |
|---|---|
| Full Name | ubiquitin specific peptidase 17 like family member 28 |
| Gene Type | protein-coding |
| Chromosomal Location | 4p16.1 (GRCh38) |
| NCBI Gene ID | 100287534 ncbi.nlm.nih.gov/gene/100287534 |
| Ensembl ID | ENSG00000228594 |
| UniProt ID | A0A0A0MRZ8 |
| OMIM ID | None |
| HGNC ID | 44432 |
| Aliases | USP17L28, DUB-3-like, FLJ43860 |
Description
USP17L28 is a protein-coding gene that belongs to the ubiquitin-specific peptidase 17 (USP17) family. It encodes a deubiquitinating enzyme that removes ubiquitin from target proteins, potentially regulating cell proliferation, apoptosis, and immune responses. The gene is located on chromosome 4p16.1, a region frequently altered in cancers. Although its specific functions are not fully characterized, it shares high sequence similarity with other USP17 family members, suggesting overlapping roles in oncogenic signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential oncogenic role via deubiquitination of substrates involved in cell cycle and apoptosis; overexpression may promote proliferation. | Inferred from USP17 family studies; direct evidence limited. |
| Lung cancer | USP17 family members are overexpressed in lung cancer tissues and cell lines, promoting cell growth. | Inferred from family member data; specific USP17L28 evidence not established. |
| Breast cancer | USP17 family members may regulate estrogen receptor signaling and cell survival. | Inferred from family member data; specific USP17L28 evidence not established. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Not determined |
| Lung | Not available | Not determined |
| Breast | Not available | Not determined |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | Not available | No data |
| HeLa | Not available | No data |
| A549 | Not available | No data |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants curated | Not applicable | Not applicable | No known pathogenic variants in ClinVar or COSMIC for USP17L28. |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations for USP17L28 in curated databases.
Gain of Function (GOF)
No evidence of gain-of-function mutations for USP17L28 in curated databases.
Dominant Negative (DN)
No evidence of dominant-negative mutations for USP17L28 in curated databases.
View complete mutation data：
Gene Ontology (GO)
| • cysteine-type deubiquitinase activity | • ubiquitin-specific protease activity |
| • proteolysis | • protein deubiquitination |
Pathways
• Ubiquitin-proteasome dependent proteolysis
• Deubiquitination
Protein Summary
The USP17L28 protein is a predicted deubiquitinating enzyme with a peptidase C19 domain. It likely removes ubiquitin from specific substrates, thereby regulating their stability and function. Due to high similarity to USP17, it may participate in cell proliferation and survival pathways. However, experimental validation is lacking, and its precise substrates and biological roles remain to be determined.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| USP17L28 Knockout HEK293 Cell Line | EDJ-KQ16071 | Human | 728400 | Details Get a Quote |
| USP17L28 Knockout HCT 116 Cell Line | EDJ-KQ45976 | Human | 728400 | Details Get a Quote |
| USP17L28 Knockout A-549 Cell Line | EDJ-KQ47190 | Human | 728400 | Details Get a Quote |
| USP17L28 Knockout HeLa Cell Line | EDJ-KQ47192 | Human | 728400 | Details Get a Quote |
