USP17L26 Gene: Ubiquitin-Specific Protease 17-Like 26
A deubiquitinase gene from the USP17 family, implicated in cell proliferation and cancer-related processes.
Gene Information Card
| Symbol | USP17L26 |
|---|---|
| Full Name | ubiquitin specific peptidase 17 like family member 26 |
| Gene Type | protein-coding |
| Chromosomal Location | 4p15.31 |
| NCBI Gene ID | 100287534 ncbi.nlm.nih.gov/gene/100287534 |
| Ensembl ID | ENSG00000235184 |
| UniProt ID | A6NK89 |
| OMIM ID | None |
| HGNC ID | 44459 |
| Aliases | USP17L26, ubiquitin specific protease 17-like 26 |
Description
USP17L26 is a protein-coding gene belonging to the USP17 family of deubiquitinating enzymes. It is located on chromosome 4p15.31 and encodes a protein that likely functions as a deubiquitinase, removing ubiquitin from target proteins. USP17 family members are known to regulate cell proliferation, cell cycle progression, and apoptosis, and are often dysregulated in various cancers. The specific function of USP17L26 is not fully characterized, but it is presumed to share functional similarities with other USP17 family members.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | USP17 family members are overexpressed in various cancers and promote cell proliferation by deubiquitinating and stabilizing proteins involved in cell cycle progression (e.g., RBBP6). | Inferred from family member studies; direct evidence for USP17L26 is limited. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | No data |
| Lung | Not available | No data |
| Breast | Not available | No data |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | No data |
| HEK293 | Not available | No data |
| MCF7 | Not available | No data |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants reported | Not applicable | Not available | No data |
Mutation functional classification
Loss of Function (LOF)
No specific loss-of-function mutations have been documented for USP17L26.
Gain of Function (GOF)
No specific gain-of-function mutations have been documented for USP17L26.
Dominant Negative (DN)
No specific dominant-negative mutations have been documented for USP17L26.
View complete mutation data：
Gene Ontology (GO)
| • cysteine-type deubiquitinase activity | • ubiquitin-specific protease activity |
| • proteolysis | • protein deubiquitination |
Pathways
• Ubiquitin-proteasome system
• Cell cycle regulation (inferred from family members)
Protein Summary
The USP17L26 protein is a putative deubiquitinase belonging to the USP17 family. It contains a peptidase C19 domain characteristic of ubiquitin-specific proteases. Its exact substrates and cellular functions remain to be fully characterized, but it is likely involved in regulating protein stability and cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| USP17L26 Knockout HEK293 Cell Line | EDJ-KQ16069 | Human | 728379 | Details Get a Quote |
| USP17L26 Knockout A-549 Cell Line | EDJ-KQ45970 | Human | 728379 | Details Get a Quote |
| USP17L26 Knockout HCT 116 Cell Line | EDJ-KQ47185 | Human | 728379 | Details Get a Quote |
| USP17L26 Knockout HeLa Cell Line | EDJ-KQ47186 | Human | 728379 | Details Get a Quote |
