USP17L25 Gene - Ubiquitin Specific Peptidase 17 Like Family Member 25
A member of the deubiquitinating enzyme family with potential roles in cell proliferation and cancer biology
Gene Information Card
| Symbol | USP17L25 |
|---|---|
| Full Name | Ubiquitin Specific Peptidase 17 Like Family Member 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 8p23.1 |
| NCBI Gene ID | 100287485 ncbi.nlm.nih.gov/gene/100287485 |
| Ensembl ID | ENSG00000227372 |
| UniProt ID | A6NKQ8 |
| OMIM ID | Not available |
| HGNC ID | 44470 |
| Aliases | USP17L25, ubiquitin specific peptidase 17-like family member 25 |
Description
USP17L25 is a protein-coding gene that belongs to the ubiquitin-specific peptidase (USP) family. It encodes a deubiquitinating enzyme that removes ubiquitin from target proteins, thereby regulating various cellular processes including cell cycle progression, apoptosis, and immune responses. The gene is located on chromosome 8p23.1, a region known for copy number variations and associations with cancer susceptibility. USP17L25 is part of a cluster of USP17-like genes that are often amplified in certain cancers, suggesting a potential role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Overexpression of USP17 family members has been linked to enhanced cell proliferation and tumor growth; USP17L25 may contribute similarly via deubiquitination of oncogenic substrates. | Inferred from family member studies (e.g., USP17L2) in cancer cell lines; direct evidence for USP17L25 is limited. |
| Inflammatory diseases | USP17 family members modulate NF-kB signaling, potentially affecting inflammatory responses. | Inferred from functional studies of USP17 in immune cells; direct evidence for USP17L25 is lacking. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression (based on RNA-seq data from GTEx, if available; otherwise inferred from family members) |
| Lung | Not available | Moderate expression (inferred from USP17 family) |
| Liver | Not available | Low expression (inferred from USP17 family) |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | USP17 family members are expressed in cervical cancer cell lines; specific data for USP17L25 not available. |
| HEK293 | Not available | Commonly used for overexpression studies; endogenous expression may be low. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants reported | Not applicable | Not applicable | No curated mutations in ClinVar or COSMIC for USP17L25. |
Mutation functional classification
Loss of Function (LOF)
No data available; loss-of-function mutations have not been characterized for USP17L25.
Gain of Function (GOF)
No data available; gain-of-function mutations have not been reported.
Dominant Negative (DN)
No data available; dominant-negative effects have not been described.
View complete mutation data：
Gene Ontology (GO)
| • cysteine-type peptidase activity | • ubiquitin-specific protease activity |
| • proteolysis | • ubiquitin-dependent protein catabolic process |
Pathways
• Ubiquitin-proteasome system
• Deubiquitination pathway
Protein Summary
The USP17L25 protein is a deubiquitinating enzyme that cleaves ubiquitin from target proteins, thereby preventing their degradation by the proteasome. It contains a peptidase C19 domain characteristic of ubiquitin-specific proteases. The protein is predicted to localize to the cytoplasm and nucleus. Its exact substrates are unknown, but based on homology to other USP17 family members, it may regulate cell cycle regulators and oncoproteins. The protein is encoded by a gene located in a region of chromosome 8 that is frequently amplified in cancers, suggesting a potential oncogenic role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| USP17L25 Knockout HEK293 Cell Line | EDJ-KQ16068 | Human | 728373 | Details Get a Quote |
| USP17L25 Knockout A-549 Cell Line | EDJ-KQ47181 | Human | 728373 | Details Get a Quote |
| USP17L25 Knockout HCT 116 Cell Line | EDJ-KQ47182 | Human | 728373 | Details Get a Quote |
| USP17L25 Knockout HeLa Cell Line | EDJ-KQ47183 | Human | 728373 | Details Get a Quote |
