USP17L23: Ubiquitin-Specific Peptidase 17-Like 23
A pseudogene-derived deubiquitinase-like gene with potential roles in cancer and immune regulation
Gene Information Card
| Symbol | USP17L23 |
|---|---|
| Full Name | Ubiquitin specific peptidase 17 like 23 |
| Gene Type | protein-coding (putative, likely pseudogene-derived) |
| Chromosomal Location | 4p16.1 (per NCBI) |
| NCBI Gene ID | 100287485 ncbi.nlm.nih.gov/gene/100287485 |
| Ensembl ID | ENSG00000235184 |
| UniProt ID | A0A0A0MRZ8 (predicted) |
| OMIM ID | Not available |
| HGNC ID | 44513 |
| Aliases | USP17L23, DUB-3-like, USP17-23 |
Description
USP17L23 is a member of the USP17-like family of deubiquitinases, located on chromosome 4p16.1. It is part of a cluster of USP17-related genes that arose from duplication events. Although annotated as protein-coding, its expression is often low and may be regulated by copy number variations. USP17 family members are implicated in cell proliferation, immune response, and cancer, but specific functional data for USP17L23 are limited.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential deubiquitinase activity may regulate oncogenic pathways, but direct evidence is lacking. | Inferred from family members; no direct ClinVar or COSMIC entries. |
| Immunodeficiency (hypothetical) | USP17 family modulates cytokine signaling; USP17L23 may have similar roles. | No direct evidence; based on homology. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression expected based on family patterns. |
| Lung | Not available | No data. |
| Breast | Not available | No data. |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | USP17 family expressed in cancer cell lines. |
| HEK293 | Not available | No specific data. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants curated | Not applicable | Not available | No known pathogenic variants. |
Mutation functional classification
Loss of Function (LOF)
No data.
Gain of Function (GOF)
No data.
Dominant Negative (DN)
No data.
View complete mutation data：
Gene Ontology (GO)
| • cysteine-type peptidase activity | • ubiquitin-specific protease activity |
| • proteolysis |
Pathways
• Ubiquitin-proteasome pathway
• Cytokine signaling (inferred)
Protein Summary
USP17L23 is a putative deubiquitinase with a catalytic domain typical of USP17 family members. It likely removes ubiquitin from target proteins, potentially stabilizing them. However, due to its pseudogene-like nature, its protein product may not be expressed at significant levels. Further studies are needed to confirm its functional relevance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| USP17L23 Knockout HEK293 Cell Line | EDJ-KQ16065 | Human | 101241878 | Details Get a Quote |
| USP17L23 Knockout HCT 116 Cell Line | EDJ-KQ45963 | Human | 101241878 | Details Get a Quote |
| USP17L23 Knockout A-549 Cell Line | EDJ-KQ47176 | Human | 101241878 | Details Get a Quote |
| USP17L23 Knockout HeLa Cell Line | EDJ-KQ47177 | Human | 101241878 | Details Get a Quote |
