USP17L15 Gene - Ubiquitin Specific Peptidase 17 Like Family Member 15
A deubiquitinase gene in the USP17 family, implicated in cell proliferation and cancer-related processes.
Gene Information Card
| Symbol | USP17L15 |
|---|---|
| Full Name | Ubiquitin specific peptidase 17 like family member 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 4p15.31 |
| NCBI Gene ID | 100287485 ncbi.nlm.nih.gov/gene/100287485 |
| Ensembl ID | ENSG00000235109 |
| UniProt ID | A6NK89 |
| OMIM ID | None |
| HGNC ID | 44422 |
| Aliases | USP17L15, ubiquitin specific peptidase 17 like family member 15 |
Description
USP17L15 is a protein-coding gene that belongs to the ubiquitin-specific peptidase 17 (USP17) family. It encodes a deubiquitinating enzyme that removes ubiquitin from target proteins, regulating various cellular processes including cell proliferation, apoptosis, and immune responses. The gene is located on chromosome 4p15.31 and is part of a cluster of USP17-like genes. Its expression is often dysregulated in cancers, suggesting a role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Overexpression of USP17 family members, including USP17L15, may promote cell proliferation and survival by deubiquitinating key oncogenic substrates, leading to enhanced tumor growth. | COSMIC and literature reports indicate altered expression in multiple cancer types. |
| Inflammatory diseases | USP17 deubiquitinases modulate NF-kB signaling, potentially affecting inflammatory responses. | Inferred from functional studies of USP17 family members. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression |
| Lung | Not available | Low expression |
| Liver | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | Cancer cell line; USP17 family expression often elevated |
| HEK293 | Not available | Embryonic kidney; used for functional studies |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| Not documented | Not documented | Not documented | No specific mutations reported in ClinVar or COSMIC for USP17L15. |
Mutation functional classification
Loss of Function (LOF)
No specific loss-of-function mutations reported for USP17L15.
Gain of Function (GOF)
No specific gain-of-function mutations reported; however, overexpression is common in cancers.
Dominant Negative (DN)
No evidence of dominant-negative effects for USP17L15.
View complete mutation data：
Gene Ontology (GO)
| • cysteine-type deubiquitinase activity | • ubiquitin-specific protease activity |
| • proteolysis | • protein deubiquitination |
| • regulation of cell proliferation |
Pathways
• Ubiquitin-proteasome pathway
• NF-kB signaling (inferred from USP17 family)
Protein Summary
The USP17L15 protein is a deubiquitinating enzyme that cleaves ubiquitin from target proteins, thereby regulating their stability and function. It contains a peptidase C19 domain characteristic of ubiquitin-specific proteases. The protein is involved in cell cycle control and apoptosis, and its dysregulation has been linked to cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| USP17L15 Knockout HEK293 Cell Line | EDJ-KQ16058 | Human | 100288520 | Details Get a Quote |
| USP17L15 Knockout HeLa Cell Line | EDJ-KQ60874 | Human | 100288520 | Details Get a Quote |
| USP17L15 Knockout A-549 Cell Line | EDJ-KQ69347 | Human | 100288520 | Details Get a Quote |
| USP17L15 Knockout HCT 116 Cell Line | EDJ-KQ77701 | Human | 100288520 | Details Get a Quote |
