USP17L10 Gene - Ubiquitin Specific Peptidase 17 Like Family Member 10
A deubiquitinase gene in the USP17 family, implicated in cell proliferation and cancer-related processes.
Gene Information Card
| Symbol | USP17L10 |
|---|---|
| Full Name | ubiquitin specific peptidase 17 like family member 10 |
| Gene Type | protein-coding |
| Chromosomal Location | 4p16.1 |
| NCBI Gene ID | 100287485 ncbi.nlm.nih.gov/gene/100287485 |
| Ensembl ID | ENSG00000235184 |
| UniProt ID | A0A0A0MRZ3 |
| OMIM ID | Not available |
| HGNC ID | 44431 |
| Aliases | USP17L10, ubiquitin specific peptidase 17-like family member 10 |
Description
USP17L10 is a protein-coding gene that belongs to the ubiquitin-specific peptidase 17 (USP17) family. It encodes a deubiquitinating enzyme that removes ubiquitin from target proteins, thereby regulating various cellular processes including cell proliferation, apoptosis, and immune responses. The gene is located on chromosome 4p16.1 and is part of a cluster of USP17-like genes. Its expression is often dysregulated in cancers, suggesting a role in tumorigenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Overexpression of USP17 family members promotes cell proliferation and survival; USP17L10 may contribute to oncogenesis through deubiquitination of key signaling proteins. | Inferred from family member studies (e.g., USP17L2) and expression data in cancer cell lines. |
| Lung cancer | USP17 family genes are overexpressed in lung cancer tissues and cell lines, potentially enhancing tumor growth. | Inferred from family member studies; direct evidence for USP17L10 is limited. |
| Breast cancer | USP17 family members are upregulated in breast cancer and may influence cell cycle progression. | Inferred from family member studies; direct evidence for USP17L10 is limited. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | No data from GTEx or Human Protein Atlas for USP17L10 specifically. |
| Lung | Not available | No data from GTEx or Human Protein Atlas for USP17L10 specifically. |
| Breast | Not available | No data from GTEx or Human Protein Atlas for USP17L10 specifically. |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | No specific data for USP17L10; family members are expressed in HeLa. |
| A549 | Not available | No specific data for USP17L10; family members are expressed in A549. |
| MCF7 | Not available | No specific data for USP17L10; family members are expressed in MCF7. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No specific variants reported | Not applicable | Not available | No curated mutations in ClinVar or COSMIC for USP17L10. |
Mutation functional classification
Loss of Function (LOF)
No evidence for loss-of-function mutations in USP17L10.
Gain of Function (GOF)
No evidence for gain-of-function mutations in USP17L10.
Dominant Negative (DN)
No evidence for dominant-negative mutations in USP17L10.
View complete mutation data：
Gene Ontology (GO)
| • cysteine-type deubiquitinase activity | • ubiquitin-specific protease activity |
| • proteolysis | • protein deubiquitination |
| • regulation of cell proliferation |
Pathways
• Ubiquitin-proteasome system
• Deubiquitination pathway
Protein Summary
The USP17L10 protein is a deubiquitinating enzyme that cleaves ubiquitin from target proteins, thereby preventing their degradation by the proteasome. It contains a peptidase C19 domain characteristic of ubiquitin-specific proteases. The protein is predicted to localize to the cytoplasm and nucleus. Its function is likely similar to other USP17 family members, which regulate cell cycle progression and apoptosis by stabilizing proteins such as CDC25A and MDM2. However, direct functional studies for USP17L10 are lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| USP17L10 Knockout HEK293 Cell Line | EDJ-KQ16054 | Human | 100287144 | Details Get a Quote |
| USP17L10 Knockout HeLa Cell Line | EDJ-KQ60853 | Human | 100287144 | Details Get a Quote |
| USP17L10 Knockout A-549 Cell Line | EDJ-KQ69327 | Human | 100287144 | Details Get a Quote |
| USP17L10 Knockout HCT 116 Cell Line | EDJ-KQ77681 | Human | 100287144 | Details Get a Quote |
