UGT2B15 Gene: UDP Glucuronosyltransferase Family 2 Member B15
Genetic and functional insights into UGT2B15, a key phase II drug-metabolizing enzyme involved in steroid and xenobiotic glucuronidation.
Gene Information Card
| Symbol | UGT2B15 |
|---|---|
| Full Name | UDP glucuronosyltransferase family 2 member B15 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 7366 ncbi.nlm.nih.gov/gene/7366 |
| Ensembl ID | ENSG00000106634 |
| UniProt ID | P54855 |
| OMIM ID | 600069 |
| HGNC ID | 12546 |
| Aliases | UGT2B8, UDPGT 2B15, UDP-glucuronosyltransferase 2B15 |
Description
UGT2B15 encodes a UDP-glucuronosyltransferase enzyme (EC 2.4.1.17) that catalyzes the glucuronidation of endogenous steroids (e.g., androgens, estrogens) and numerous xenobiotics. This phase II conjugation reaction enhances the water solubility and elimination of substrates. The enzyme is primarily expressed in the liver, prostate, and other steroid-responsive tissues. Genetic polymorphisms in UGT2B15 influence enzyme activity and are associated with altered drug metabolism and cancer risk.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Altered androgen glucuronidation may affect intraprostatic androgen levels and tumor progression. | PMID: 10652368, 11574763 |
| Breast cancer | Variants in UGT2B15 modulate estrogen metabolism and may influence breast cancer susceptibility. | PMID: 15642720 |
| Osteoporosis | UGT2B15-mediated glucuronidation of androgens may impact bone mineral density. | PMID: 15831596 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Prostate | 8.3 | Medium |
| Adrenal gland | 6.1 | Medium |
| Kidney | 2.4 | Low |
| Small intestine | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| LNCaP | 9.7 | Prostate cancer cell line |
| MCF-7 | 4.5 | Breast cancer cell line |
| Caco-2 | 2.1 | Colorectal adenocarcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs1902023 (c.253G>T, p.D85Y) | SNP | 0.25 (global MAF) | Reduced enzyme activity; altered steroid glucuronidation |
| rs4148269 (c.1568C>T, p.T523I) | SNP | 0.12 (global MAF) | Decreased catalytic efficiency for some substrates |
| rs11692021 (c.488C>T, p.P163L) | SNP | 0.05 (global MAF) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
rs1902023 (p.D85Y) is associated with reduced glucuronidation activity toward androgens.
Gain of Function (GOF)
No well-characterized gain-of-function variants reported.
Dominant Negative (DN)
Not described for UGT2B15.
View complete mutation data：
Gene Ontology (GO)
| • glucuronosyltransferase activity (GO:0015020) | • metabolic process (GO:0008152) |
| • endoplasmic reticulum (GO:0005783) | • cellular glucuronidation (GO:0052695) |
Pathways
• Phase II conjugation – Glucuronidation (Reactome: R-HSA-156588)
• Androgen and estrogen metabolism (KEGG: hsa00150)
• Drug metabolism – glucuronidation (KEGG: hsa00983)
Protein Summary
UGT2B15 is a 530-amino-acid transmembrane protein localized to the endoplasmic reticulum. It belongs to the UDP-glucuronosyltransferase 2B subfamily and conjugates UDP-glucuronic acid to a variety of lipophilic substrates, including steroid hormones (e.g., dihydrotestosterone, androstane-3α,17β-diol) and drugs (e.g., oxazepam, lorazepam). The enzyme exhibits broad substrate specificity and is a key determinant of interindividual variability in drug clearance and hormone homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UGT2B15 Knockout HEK293 Cell Line | EDJ-KQ5996 | Human | 7366 | Details Get a Quote |
| UGT2B15 Knockout HeLa Cell Line | EDJ-KQ54726 | Human | 7366 | Details Get a Quote |
| UGT2B15 Knockout A-549 Cell Line | EDJ-KQ63217 | Human | 7366 | Details Get a Quote |
| UGT2B15 Knockout HCT 116 Cell Line | EDJ-KQ71683 | Human | 7366 | Details Get a Quote |
