UGT2B11: UDP-Glucuronosyltransferase 2 Family, Polypeptide B11
A phase II drug-metabolizing enzyme involved in glucuronidation of endogenous and xenobiotic compounds.
Gene Information Card
| Symbol | UGT2B11 |
|---|---|
| Full Name | UDP Glucuronosyltransferase Family 2 Member B11 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 10720 ncbi.nlm.nih.gov/gene/10720 |
| Ensembl ID | ENSG00000138069 |
| UniProt ID | O75310 |
| OMIM ID | 603064 |
| HGNC ID | 12549 |
| Aliases | UDPGT2B11, UGT2B9Y, UGT2B11v1 |
Description
UGT2B11 encodes a member of the UDP-glucuronosyltransferase (UGT) family, specifically the UGT2B subfamily. These enzymes catalyze the conjugation of glucuronic acid to a variety of endogenous substrates (e.g., bilirubin, steroid hormones, bile acids) and xenobiotics (e.g., drugs, environmental chemicals), facilitating their elimination. UGT2B11 is expressed primarily in the liver and is involved in the glucuronidation of certain steroids and drugs. Its activity can influence drug clearance and susceptibility to toxicity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hyperbilirubinemia (indirect) | Deficient glucuronidation of bilirubin; UGT2B11 may contribute to residual activity in some forms. | Limited direct evidence; inferred from UGT family function. |
| Drug-induced liver injury (DILI) | Reduced UGT2B11 activity may impair clearance of hepatotoxic drugs. | Association studies; functional polymorphisms. |
| Cancer (hormone-sensitive) | Altered steroid glucuronidation may affect hormone levels. | Expression studies in breast and prostate tissues. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Kidney | 3.2 | Medium |
| Small intestine | 2.1 | Medium |
| Colon | 1.8 | Low |
| Prostate | 1.5 | Low |
| Breast | 0.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 8.4 | Hepatocellular carcinoma cell line |
| Caco-2 | 3.1 | Colorectal adenocarcinoma cell line |
| MCF-7 | 1.2 | Breast cancer cell line |
| LNCaP | 1.0 | Prostate cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon; functional impact unknown. |
| c.454G>A (p.Ala152Thr) | missense | 0.02% | Reduced enzyme activity in vitro. |
| c.1000C>T (p.Arg334Cys) | missense | 0.01% | Altered substrate specificity. |
Mutation functional classification
Loss of Function (LOF)
p.Met1? and p.Ala152Thr variants reduce or abolish glucuronidation activity.
Gain of Function (GOF)
No gain-of-function variants reported.
Dominant Negative (DN)
Not described for UGT2B11.
View complete mutation data：
Gene Ontology (GO)
| • glucuronosyltransferase activity (GO:0015020) | • cellular glucuronidation (GO:0052695) |
| • endoplasmic reticulum membrane (GO:0005783) | • xenobiotic metabolic process (GO:0006805) |
| • steroid metabolic process (GO:0008202) |
Pathways
• Biological oxidations (Reactome: R-HSA-211859)
• Glucuronidation (Reactome: R-HSA-156588)
• Phase II conjugation (KEGG: map00982)
Protein Summary
UGT2B11 is a 529-amino acid transmembrane protein localized to the endoplasmic reticulum. It contains a signal peptide, a substrate-binding domain, and a UDP-glucuronic acid binding domain. The enzyme conjugates glucuronic acid to various lipophilic substrates, increasing their water solubility for excretion. UGT2B11 shares high sequence homology with other UGT2B members but exhibits distinct substrate preferences, including certain steroids and nonsteroidal anti-inflammatory drugs.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UGT2B11 Knockout HEK293 Cell Line | EDJ-KQ7139 | Human | 10720 | Details Get a Quote |
| UGT2B11 Knockout HeLa Cell Line | EDJ-KQ55471 | Human | 10720 | Details Get a Quote |
| UGT2B11 Knockout A-549 Cell Line | EDJ-KQ63956 | Human | 10720 | Details Get a Quote |
| UGT2B11 Knockout HCT 116 Cell Line | EDJ-KQ72412 | Human | 10720 | Details Get a Quote |
