UGT2B10
UDP Glucuronosyltransferase Family 2 Member B10
Gene Information Card
| Symbol | UGT2B10 |
|---|---|
| Full Name | UDP Glucuronosyltransferase Family 2 Member B10 |
| Gene Type | protein-coding |
| Chromosomal Location | 4q13.3 |
| NCBI Gene ID | 7365 ncbi.nlm.nih.gov/gene/7365 |
| Ensembl ID | ENSG00000109927 |
| UniProt ID | P36537 |
| OMIM ID | 600069 |
| HGNC ID | 12546 |
| Aliases | UGT2B9, UDPGT 2B10, UDP-glucuronosyltransferase 2B10 |
Description
UGT2B10 encodes a UDP-glucuronosyltransferase enzyme that catalyzes the glucuronidation of various endogenous and exogenous compounds, including drugs, bilirubin, and steroid hormones. It is primarily expressed in the liver and plays a key role in phase II drug metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hyperbilirubinemia | Deficient glucuronidation of bilirubin | ClinVar |
| Drug-induced liver injury | Altered metabolism of hepatotoxic drugs | NCBI Gene |
| Cancer (various) | Polymorphisms affecting carcinogen detoxification | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Kidney | 3.2 | Medium |
| Adrenal gland | 1.8 | Low |
| Small intestine | 0.9 | Low |
| Lung | 0.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 8.1 | Liver cancer cell line |
| HEK293 | 0.3 | Embryonic kidney |
| Caco-2 | 0.1 | Colorectal adenocarcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.244C>T (p.Arg82*) | Nonsense | <0.01% | Loss of function |
| c.488G>A (p.Arg163His) | Missense | 0.5% | Reduced enzyme activity |
| c.721C>T (p.Arg241Trp) | Missense | 0.2% | Altered substrate specificity |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift variants leading to truncated protein
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • glucuronosyltransferase activity (GO:0015020) | • metabolic process (GO:0008152) |
| • endoplasmic reticulum (GO:0005783) | • plasma membrane (GO:0005886) |
Pathways
• Phase II conjugation (glucuronidation)
• Bilirubin metabolism
• Steroid hormone metabolism
Protein Summary
UGT2B10 is a 528-amino acid transmembrane protein localized to the endoplasmic reticulum. It catalyzes the transfer of glucuronic acid from UDP-glucuronic acid to a variety of substrates, facilitating their excretion. The enzyme is critical for the clearance of drugs such as nicotine and opioids.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UGT2B10 Knockout HEK293 Cell Line | EDJ-KQ50704 | Human | 7365 | Details Get a Quote |
| UGT2B10 Knockout HeLa Cell Line | EDJ-KQ54725 | Human | 7365 | Details Get a Quote |
| UGT2B10 Knockout A-549 Cell Line | EDJ-KQ63216 | Human | 7365 | Details Get a Quote |
| UGT2B10 Knockout HCT 116 Cell Line | EDJ-KQ71682 | Human | 7365 | Details Get a Quote |
