UCN3 (Urocortin 3)
A member of the corticotropin-releasing factor (CRF) family involved in stress response and energy homeostasis
Gene Information Card
| Symbol | UCN3 |
|---|---|
| Full Name | Urocortin 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 10p15.1 |
| NCBI Gene ID | 114131 ncbi.nlm.nih.gov/gene/114131 |
| Ensembl ID | ENSG00000148773 |
| UniProt ID | Q969E3 |
| OMIM ID | 605902 |
| HGNC ID | 12519 |
| Aliases | SRP, SCP, urocortin III |
Description
UCN3 encodes urocortin 3, a member of the corticotropin-releasing factor (CRF) family. This neuropeptide binds selectively to CRF receptor type 2 (CRHR2) and is involved in stress response, energy balance, and cardiovascular regulation. It is expressed primarily in the central nervous system and peripheral tissues such as pancreas and gastrointestinal tract.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diabetes mellitus type 2 | UCN3 modulates insulin secretion via CRHR2; altered expression may contribute to beta-cell dysfunction | PMID: 17977942 |
| Obesity | UCN3 regulates appetite and energy expenditure; polymorphisms associated with metabolic traits | PMID: 20068047 |
| Anxiety disorders | UCN3 signaling in amygdala modulates stress and anxiety-like behaviors | PMID: 15385444 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.8 | Low |
| Pancreas | 4.2 | Medium |
| Gastrointestinal tract | 3.1 | Medium |
| Heart | 1.5 | Low |
| Skeletal muscle | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.1 | Not detected |
| SH-SY5Y | 0.5 | Low expression |
| MIN6 (mouse beta-cell) | 5.0 | High expression (rodent model) |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.214C>T (p.Arg72Cys) | missense | <0.01% | May alter receptor binding affinity |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • hormone activity (GO:0005179) | • neuropeptide signaling pathway (GO:0007218) |
| • response to insulin stimulus (GO:0032868) | • glucose homeostasis (GO:0042593) |
| • response to hypoxia (GO:0001666) |
Pathways
• Corticotropin-releasing hormone signaling pathway (KEGG: hsa04061)
• Neuroactive ligand-receptor interaction (KEGG: hsa04080)
Protein Summary
Urocortin 3 is a 38-amino acid peptide that acts as a selective agonist for CRF receptor type 2 (CRHR2). It is synthesized as a preproprotein and processed to the mature active form. The peptide plays roles in stress adaptation, energy metabolism, and cardiovascular function. Its structure includes a conserved alpha-helical region critical for receptor binding.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UCN3 Knockout HEK293 Cell Line | EDJ-KQ7438 | Human | 114131 | Details Get a Quote |
| UCN3 Knockout HeLa Cell Line | EDJ-KQ57917 | Human | 114131 | Details Get a Quote |
| UCN3 Knockout A-549 Cell Line | EDJ-KQ66407 | Human | 114131 | Details Get a Quote |
| UCN3 Knockout HCT 116 Cell Line | EDJ-KQ74834 | Human | 114131 | Details Get a Quote |
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