UCN2 (Urocortin 2)
A member of the corticotropin-releasing factor (CRF) family involved in stress response and cardiovascular regulation
Gene Information Card
| Symbol | UCN2 |
|---|---|
| Full Name | Urocortin 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 90226 ncbi.nlm.nih.gov/gene/90226 |
| Ensembl ID | ENSG00000145012 |
| UniProt ID | Q96RE3 |
| OMIM ID | 605902 |
| HGNC ID | 12519 |
| Aliases | URP, UCN-II, urocortin-related peptide |
Description
UCN2 encodes urocortin 2, a member of the corticotropin-releasing factor (CRF) family. This neuropeptide selectively binds to the CRF type 2 receptor (CRHR2) and is involved in stress response, anxiety, feeding behavior, and cardiovascular regulation. It is expressed in the brain, heart, and peripheral tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Heart Failure | Urocortin 2 has cardioprotective effects via CRHR2 activation; altered expression observed in failing hearts | PMID: 16968950 |
| Anxiety Disorders | UCN2 modulates stress and anxiety-like behaviors through CRHR2 in the brain | PMID: 15009638 |
| Obesity | Urocortin 2 suppresses appetite and may influence energy homeostasis | PMID: 11739391 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.2 | Low |
| Heart | 1.5 | Medium |
| Skeletal Muscle | 0.8 | Low |
| Pancreas | 0.3 | Low |
| Placenta | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.0 | Not expressed |
| SH-SY5Y | 0.1 | Low expression |
| H9c2 | 1.2 | Moderate expression in rat cardiomyocyte line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Predicted benign; no known disease association |
| c.124C>T | Synonymous | <0.01% | No functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • hormone activity (GO:0005179) | • extracellular region (GO:0005576) |
| • neuropeptide signaling pathway (GO:0007218) | • G protein-coupled receptor binding (GO:0001664) |
| • vasodilation (GO:0042310) |
Pathways
• Corticotropin-releasing hormone signaling pathway (KEGG: hsa04061)
• Neuroactive ligand-receptor interaction (KEGG: hsa04080)
Protein Summary
Urocortin 2 is a 38-amino acid peptide hormone that binds specifically to CRHR2. It is synthesized as a preproprotein and processed to the mature active form. The peptide plays roles in stress adaptation, cardiovascular protection, and metabolic regulation. Its structure includes a conserved CRF family motif.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UCN2 Knockout HEK293 Cell Line | EDJ-KQ10570 | Human | 90226 | Details Get a Quote |
| UCN2 Knockout A-549 Cell Line | EDJ-KQ38030 | Human | 90226 | Details Get a Quote |
| UCN2 Knockout HeLa Cell Line | EDJ-KQ38031 | Human | 90226 | Details Get a Quote |
| UCN2 Knockout HCT 116 Cell Line | EDJ-KQ74679 | Human | 90226 | Details Get a Quote |
