UBXN11: UBX Domain Protein 11
A regulator of endoplasmic reticulum-associated degradation (ERAD) and cell cycle progression
Gene Information Card
| Symbol | UBXN11 |
|---|---|
| Full Name | UBX Domain Protein 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.11 |
| NCBI Gene ID | 91544 ncbi.nlm.nih.gov/gene/91544 |
| Ensembl ID | ENSG00000162614 |
| UniProt ID | Q5T0T0 |
| OMIM ID | 616450 |
| HGNC ID | 29262 |
| Aliases | SOC, SOC1, UBX domain-containing protein 11, SOCS box-containing protein |
Description
UBXN11 (UBX Domain Protein 11) encodes a protein containing a UBX domain, which is involved in ubiquitin-mediated proteolysis and endoplasmic reticulum-associated degradation (ERAD). The protein also contains a SOCS box, suggesting a role in cytokine signaling and protein degradation. UBXN11 is implicated in cell cycle regulation and may function as a tumor suppressor. It is located on chromosome 1p36.11, a region frequently deleted in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Loss of heterozygosity at 1p36.11 may lead to reduced UBXN11 expression, impairing ERAD and promoting genomic instability. | COSMIC; PMID: 23431171 |
| Neuroblastoma | Deletion of 1p36 region including UBXN11 is associated with poor prognosis. | PMID: 15696205 |
| Hepatocellular carcinoma | Downregulation of UBXN11 correlates with tumor progression and metastasis. | PMID: 25944712 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 8.2 | Medium |
| Brain | 5.1 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
| Heart | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 6.5 | Embryonic kidney cells; moderate expression |
| HeLa | 4.2 | Cervical cancer cells; low expression |
| HepG2 | 3.1 | Hepatocellular carcinoma; low expression |
| SH-SY5Y | 2.0 | Neuroblastoma; very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.457G>A (p.Gly153Ser) | Missense | <0.01% | Predicted benign by in silico tools |
| c.832_833del (p.Leu278fs) | Frameshift | <0.01% | Loss of function; likely pathogenic |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Leu278fs) lead to truncated protein and loss of UBX domain, impairing ERAD function.
Gain of Function (GOF)
No documented gain-of-function mutations.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-dependent protein catabolic process | • endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process |
| • protein ubiquitination | • cell cycle |
| • protein binding | • UBX domain binding |
Pathways
• Endoplasmic reticulum-associated degradation (ERAD)
• Ubiquitin-proteasome system
• Cytokine signaling (SOCS box-mediated)
Protein Summary
UBXN11 is a 441-amino acid protein containing an N-terminal UBX domain and a C-terminal SOCS box. The UBX domain mediates interaction with p97/VCP, a key ATPase in ERAD, while the SOCS box recruits E3 ubiquitin ligase complexes. Through these interactions, UBXN11 facilitates the extraction and degradation of misfolded proteins from the ER. It also localizes to the centrosome and regulates mitotic progression. Loss of UBXN11 leads to ER stress and chromosomal instability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UBXN11 Knockout HEK293 Cell Line | EDJ-KQ16017 | Human | 91544 | Details Get a Quote |
| UBXN11 Knockout A-549 Cell Line | EDJ-KQ47110 | Human | 91544 | Details Get a Quote |
| UBXN11 Knockout HCT 116 Cell Line | EDJ-KQ47111 | Human | 91544 | Details Get a Quote |
| UBXN11 Knockout HeLa Cell Line | EDJ-KQ47112 | Human | 91544 | Details Get a Quote |
