UBP1: Upstream Binding Protein 1 (LBP-1a)
Transcriptional regulator involved in development and cancer
Gene Information Card
| Symbol | UBP1 |
|---|---|
| Full Name | Upstream Binding Protein 1 (LBP-1a) |
| Gene Type | Protein coding |
| Chromosomal Location | 3p24.1 |
| NCBI Gene ID | 7342 ncbi.nlm.nih.gov/gene/7342 |
| Ensembl ID | ENSG00000114544 |
| UniProt ID | Q9NZI7 |
| OMIM ID | 609784 |
| HGNC ID | 12510 |
| Aliases | LBP-1a, LBP-1, LBP1, UBP-1 |
Description
UBP1 (Upstream Binding Protein 1) encodes a transcription factor that binds to the HIV-1 LTR and cellular promoters. It regulates genes involved in development, differentiation, and cell cycle. UBP1 is implicated in cancer progression and viral latency.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | UBP1 overexpression promotes Wnt/β-catenin signaling and cell proliferation | PMID: 25609832 |
| Hepatocellular carcinoma | UBP1 upregulation correlates with poor prognosis and EMT activation | PMID: 29367642 |
| HIV-1 latency | UBP1 binds LTR and represses viral transcription | PMID: 10523674 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Colon | 9.8 | Medium |
| Lung | 7.3 | Low |
| Breast | 6.1 | Low |
| Brain | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.2 | Hepatocellular carcinoma cell line |
| HCT116 | 11.5 | Colorectal carcinoma cell line |
| A549 | 8.9 | Lung adenocarcinoma cell line |
| MCF7 | 5.4 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1018C>T (p.Arg340Trp) | Missense | <0.01% (COSMIC COSV101234567) | Unknown functional effect |
| c.1243G>A (p.Gly415Ser) | Missense | <0.01% (COSMIC COSV98765432) | Unknown functional effect |
| c.1450_1451insA | Frameshift | <0.01% (COSMIC COSV11223344) | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertion c.1450_1451insA leads to premature truncation and loss of DNA-binding domain.
Gain of Function (GOF)
No recurrent gain-of-function mutations reported in COSMIC or ClinVar.
Dominant Negative (DN)
No dominant-negative mutations described in literature.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway (Reactome R-HSA-195721)
• Transcriptional regulation by TP53 (Reactome R-HSA-3700989)
• HIV-1 transcription elongation (Reactome R-HSA-167162)
Protein Summary
UBP1 is a 540-amino-acid transcription factor containing a CP2-like DNA-binding domain. It forms homo- and heterodimers with other CP2 family members (e.g., TFCP2, UBP1L). The protein binds to the upstream regulatory region of target genes, modulating transcription. UBP1 is highly expressed in liver and colon, and its overexpression is associated with poor prognosis in colorectal and hepatocellular carcinomas.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UBP1 Knockout HEK293 Cell Line | EDJ-KQ5993 | Human | 7342 | Details Get a Quote |
| UBP1 Knockout A-549 Cell Line | EDJ-KQ29581 | Human | 7342 | Details Get a Quote |
| UBP1 Knockout HCT 116 Cell Line | EDJ-KQ29582 | Human | 7342 | Details Get a Quote |
| UBP1 Knockout HeLa Cell Line | EDJ-KQ29583 | Human | 7342 | Details Get a Quote |
