UBE2W: Ubiquitin Conjugating Enzyme E2 W
A ubiquitin-conjugating enzyme involved in protein ubiquitination and cellular stress responses.
Gene Information Card
| Symbol | UBE2W |
|---|---|
| Full Name | Ubiquitin Conjugating Enzyme E2 W |
| Gene Type | Protein coding |
| Chromosomal Location | 8q21.11 |
| NCBI Gene ID | 55284 ncbi.nlm.nih.gov/gene/55284 |
| Ensembl ID | ENSG00000104331 |
| UniProt ID | Q96B02 |
| OMIM ID | 614332 |
| HGNC ID | 12489 |
| Aliases | FLJ20445, UBC6, UBE2W1 |
Description
UBE2W encodes a member of the ubiquitin-conjugating enzyme (E2) family. This enzyme catalyzes the second step in ubiquitination, transferring ubiquitin from an E1 enzyme to a substrate-specific E3 ligase. UBE2W is involved in protein quality control, DNA damage response, and regulation of transcription factors. It is widely expressed and has been implicated in cancer and neurodegenerative disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered ubiquitination of tumor suppressors (e.g., p53) | COSMIC, ClinVar |
| Neurodegeneration | Dysregulation of protein degradation pathways | UniProt, literature |
| Developmental disorders | Potential role in ubiquitin signaling | OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Brain | 10.8 | Medium |
| Lung | 8.5 | Low |
| Liver | 6.3 | Low |
| Heart | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.4 | Moderate expression |
| HeLa | 9.8 | Moderate expression |
| K562 | 7.2 | Low expression |
| MCF7 | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.1% | Unknown functional impact |
| c.463G>A (p.Gly155Ser) | Missense | <0.1% | Potential loss of function |
| c.1A>G (p.Met1Val) | Start loss | Rare | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense mutations in the active site or start codon loss may impair ubiquitin conjugation.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin conjugating enzyme activity | • protein ubiquitination |
| • ubiquitin-dependent protein catabolic process | • DNA repair |
| • response to stress |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Protein processing in endoplasmic reticulum (KEGG: hsa04141)
Protein Summary
UBE2W is a 170-amino acid protein with a conserved ubiquitin-conjugating catalytic domain. It interacts with various E3 ligases to ubiquitinate substrates, including p53 and histones. The protein is localized to the nucleus and cytoplasm and is essential for cellular homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UBE2W Knockout HEK293 Cell Line | EDJ-KQ16010 | Human | 55284 | Details Get a Quote |
| UBE2W Knockout A-549 Cell Line | EDJ-KQ47096 | Human | 55284 | Details Get a Quote |
| UBE2W Knockout HCT 116 Cell Line | EDJ-KQ47097 | Human | 55284 | Details Get a Quote |
| UBE2W Knockout HeLa Cell Line | EDJ-KQ47098 | Human | 55284 | Details Get a Quote |
| UBE2W Knockout HAP1 Cell Line | EDC08006 | Human | 55284 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
