UBE2S
Ubiquitin Conjugating Enzyme E2 S
Gene Information Card
| Symbol | UBE2S |
|---|---|
| Full Name | Ubiquitin Conjugating Enzyme E2 S |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.43 |
| NCBI Gene ID | 27338 ncbi.nlm.nih.gov/gene/27338 |
| Ensembl ID | ENSG00000105329 |
| UniProt ID | Q16763 |
| OMIM ID | 609863 |
| HGNC ID | 12496 |
| Aliases | E2-EPF, E2EPF, EPF5 |
Description
UBE2S encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein catalyzes the attachment of ubiquitin to target proteins, playing a key role in ubiquitin-dependent proteolysis. UBE2S is involved in cell cycle progression, particularly in the anaphase-promoting complex/cyclosome (APC/C)-mediated degradation of substrates, and has been implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of UBE2S promotes cell proliferation and tumor growth by enhancing ubiquitination and degradation of tumor suppressors. | PMID: 25944712 |
| Colorectal cancer | UBE2S upregulation correlates with poor prognosis and promotes metastasis via EMT induction. | PMID: 29367600 |
| Hepatocellular carcinoma | UBE2S overexpression enhances cell cycle progression and inhibits apoptosis. | PMID: 30523332 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Lymph node | 18.2 | Medium |
| Bone marrow | 15.1 | Medium |
| Brain | 4.3 | Low |
| Liver | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 22.1 | Cervical cancer cell line |
| HEK 293 | 19.7 | Embryonic kidney cell line |
| MCF7 | 16.4 | Breast cancer cell line |
| HCT116 | 14.9 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional impact |
| c.214C>T | missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in UBE2S.
Gain of Function (GOF)
Overexpression in multiple cancers suggests potential gain-of-function role.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin conjugating enzyme activity | • protein ubiquitination |
| • cell cycle | • anaphase-promoting complex-dependent catabolic process |
| • nucleus | • cytoplasm |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Cell cycle (KEGG: hsa04110)
• APC/C-mediated degradation of cell cycle proteins
Protein Summary
UBE2S is a 222-amino acid protein with a conserved ubiquitin-conjugating (UBC) domain. It functions as an E2 ubiquitin-conjugating enzyme, transferring ubiquitin from an E1 enzyme to specific substrates in conjunction with E3 ligases. UBE2S is essential for the processive ubiquitin chain elongation on APC/C substrates, thereby regulating mitotic exit and genomic stability.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UBE2S Knockout HEK293 Cell Line | EDJ-KQ3959 | Human | 27338 | Details Get a Quote |
| UBE2S Knockout A-549 Cell Line | EDJ-KQ26228 | Human | 27338 | Details Get a Quote |
| UBE2S Knockout HCT 116 Cell Line | EDJ-KQ26229 | Human | 27338 | Details Get a Quote |
| UBE2S Knockout HeLa Cell Line | EDJ-KQ26230 | Human | 27338 | Details Get a Quote |
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