UBE2C
Ubiquitin Conjugating Enzyme E2 C
Gene Information Card
| Symbol | UBE2C |
|---|---|
| Full Name | Ubiquitin Conjugating Enzyme E2 C |
| Gene Type | Protein coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 11065 ncbi.nlm.nih.gov/gene/11065 |
| Ensembl ID | ENSG00000175063 |
| UniProt ID | O00762 |
| OMIM ID | 605574 |
| HGNC ID | 12492 |
| Aliases | UBCH10, dJ247L16.3, UbcH10 |
Description
UBE2C encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is essential for the destruction of mitotic cyclins and cell cycle progression. It functions as the E2 enzyme for the anaphase-promoting complex/cyclosome (APC/C), targeting substrates for degradation by the proteasome. Overexpression of UBE2C is frequently observed in various cancers and is associated with chromosomal instability and poor prognosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression leads to accelerated mitotic exit and aneuploidy | PMID: 15199144, COSMIC |
| Colorectal cancer | Upregulation promotes proliferation and invasion | PMID: 19696743, COSMIC |
| Lung cancer | High expression correlates with poor survival and metastasis | PMID: 23382250, COSMIC |
| Ovarian cancer | Amplification and overexpression drive tumorigenesis | PMID: 17638962, COSMIC |
| Prostate cancer | UBE2C overexpression linked to aggressive disease | PMID: 24755471, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 48.5 | High |
| Bone marrow | 32.1 | High |
| Lymph node | 28.7 | High |
| Spleen | 25.3 | High |
| Thymus | 22.0 | High |
| Brain | 1.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 35.2 | Cervical cancer cell line; high expression |
| MCF7 | 28.9 | Breast cancer cell line; high expression |
| A549 | 22.4 | Lung cancer cell line; moderate expression |
| HCT116 | 30.1 | Colorectal cancer cell line; high expression |
| K562 | 18.5 | Leukemia cell line; moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Loss of start codon; likely loss of function |
| c.169C>T (p.Arg57Trp) | Missense | <0.1% | Unknown functional effect |
| c.344A>G (p.Asn115Ser) | Missense | <0.1% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Rare truncating or start-loss mutations may impair ubiquitin conjugation activity.
Gain of Function (GOF)
Gene amplification and overexpression are common in cancers, acting as a gain-of-function mechanism.
Dominant Negative (DN)
No dominant negative mutations have been reported.
View complete mutation data：
Gene Ontology (GO)
| • ubiquitin-protein transferase activity | • protein ubiquitination |
| • cell cycle | • mitotic cell cycle |
| • anaphase-promoting complex-dependent catabolic process | • ubiquitin conjugating enzyme activity |
Pathways
• Cell Cycle (KEGG hsa04110)
• Ubiquitin mediated proteolysis (KEGG hsa04120)
• APC/C-mediated degradation of cell cycle proteins (Reactome R-HSA-174178)
Protein Summary
UBE2C (UbcH10) is a 179-amino acid protein with a molecular weight of approximately 20 kDa. It contains a conserved ubiquitin-conjugating (UBC) domain and a catalytic cysteine residue (Cys114) required for thioester bond formation with ubiquitin. The protein interacts with the APC/C complex and is essential for ubiquitin chain elongation on substrates such as cyclin B and securin. Its expression is tightly regulated during the cell cycle, peaking in G2/M phase.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| UBE2C Knockout HEK293 Cell Line | EDJ-KQ7264 | Human | 11065 | Details Get a Quote |
| UBE2C Knockout A-549 Cell Line | EDJ-KQ32281 | Human | 11065 | Details Get a Quote |
| UBE2C Knockout HCT 116 Cell Line | EDJ-KQ32282 | Human | 11065 | Details Get a Quote |
| UBE2C Knockout HeLa Cell Line | EDJ-KQ32283 | Human | 11065 | Details Get a Quote |
| UBE2C Knockout HAP1 Cell Line | EDC08011 | Human | 11065 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
