TYRO3
TYRO3 Protein Tyrosine Kinase
Gene Information Card
| Symbol | TYRO3 |
|---|---|
| Full Name | TYRO3 protein tyrosine kinase |
| Gene Type | protein-coding |
| Chromosomal Location | 15q15.1 |
| NCBI Gene ID | 7301 ncbi.nlm.nih.gov/gene/7301 |
| Ensembl ID | ENSG00000167900 |
| UniProt ID | Q06418 |
| OMIM ID | 600341 |
| HGNC ID | 12446 |
| Aliases | BYK, DTK, RSE, SKY, TIF |
Description
TYRO3 is a member of the TAM receptor tyrosine kinase family (TYRO3, AXL, MERTK). It is involved in cell survival, proliferation, migration, and phagocytosis. TYRO3 is activated by the ligands GAS6 and PROS1 and plays roles in immune regulation, spermatogenesis, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Non-small cell lung cancer | Overexpression and activation promote tumor growth and metastasis | PMID: 25605247 |
| Acute myeloid leukemia | TYRO3 signaling supports leukemic cell survival | PMID: 23509156 |
| Systemic lupus erythematosus | Loss of TYRO3 function impairs clearance of apoptotic cells | PMID: 15240667 |
| Retinitis pigmentosa | Mutations in TYRO3 associated with retinal degeneration | PMID: 26908613 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.3 | Medium |
| Lung | 8.7 | Low |
| Liver | 6.2 | Low |
| Kidney | 10.1 | Medium |
| Testis | 25.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 | 15.2 | Lung cancer cell line |
| HEK293 | 9.8 | Embryonic kidney cells |
| K562 | 22.1 | Leukemia cell line |
| MCF7 | 7.5 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.1% | Reduced kinase activity |
| c.1567G>A (p.Gly523Arg) | Missense | <0.1% | Unknown functional effect |
| c.2101_2102insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the kinase domain lead to loss of catalytic activity.
Gain of Function (GOF)
Missense mutations in the activation loop may increase kinase activity, though rare.
Dominant Negative (DN)
Truncated forms lacking the kinase domain but retaining the extracellular domain may interfere with wild-type receptor signaling.
View complete mutation data：
Gene Ontology (GO)
| • ATP binding | • protein tyrosine kinase activity |
| • receptor signaling protein tyrosine kinase activity | • transmembrane receptor protein tyrosine kinase signaling pathway |
| • phagocytosis | • cell migration |
Pathways
• TAM receptor signaling
• Apoptotic cell clearance
• PI3K-Akt signaling pathway
• MAPK signaling pathway
Protein Summary
TYRO3 is a transmembrane receptor tyrosine kinase composed of two immunoglobulin-like domains and two fibronectin type III domains in the extracellular region, and a cytoplasmic tyrosine kinase domain. It is activated by binding of GAS6 or PROS1, leading to autophosphorylation and downstream signaling that regulates cell survival, proliferation, and phagocytosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TYRO3 Knockout HEK293 Cell Line | EDJ-KQ17793 | Human | 7301 | Details Get a Quote |
| TYRO3 Knockout A-549 Cell Line | EDJ-KQ19882 | Human | 7301 | Details Get a Quote |
| TYRO3 Knockout HCT 116 Cell Line | EDJ-KQ19883 | Human | 7301 | Details Get a Quote |
| TYRO3 Knockout HeLa Cell Line | EDJ-KQ19884 | Human | 7301 | Details Get a Quote |
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