TUT7: Terminal Uridylyl Transferase 7
A key regulator of RNA uridylation, microRNA processing, and telomere maintenance
Gene Information Card
| Symbol | TUT7 |
|---|---|
| Full Name | Terminal Uridylyl Transferase 7 |
| Gene Type | Protein-coding |
| Chromosomal Location | 9q21.33 |
| NCBI Gene ID | 79657 ncbi.nlm.nih.gov/gene/79657 |
| Ensembl ID | ENSG00000107175 |
| UniProt ID | Q5VU43 |
| OMIM ID | 617202 |
| HGNC ID | 29131 |
| Aliases | ZCCHC6, TUTase 7, zinc finger CCHC domain-containing protein 6 |
Description
TUT7 (Terminal Uridylyl Transferase 7) encodes a member of the terminal uridylyltransferase (TUTase) family. The protein catalyzes the addition of uridine residues to the 3' end of RNA molecules, playing critical roles in microRNA (miRNA) processing, RNA stability, and telomere maintenance. TUT7 is involved in the uridylation of pre-let-7 miRNA, regulating its maturation, and participates in the regulation of telomerase activity. It is also implicated in the cellular response to DNA damage and viral infection.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Dysregulation of miRNA processing and telomere maintenance via altered uridylation | COSMIC; PMID: 25775514 |
| Telomere-related disorders | Modulation of telomerase activity through TUT7-mediated uridylation of telomerase RNA | PMID: 25775514 |
| Viral infections | TUT7-mediated uridylation of viral RNA affects replication and immune evasion | PMID: 29100055 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Medium |
| Lymph node | 6.1 | Low |
| Brain | 4.3 | Low |
| Liver | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 10.5 | Medium expression |
| K562 | 8.0 | Medium expression |
| HepG2 | 5.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function; truncation of catalytic domain |
| c.567G>A (p.Glu189Lys) | Missense | <0.1% | Unknown; predicted damaging by SIFT |
| c.2345_2346insA | Frameshift | <0.1% | Loss of function; premature stop codon |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations in TUT7 lead to truncated proteins lacking the catalytic TUTase domain, impairing RNA uridylation activity.
Gain of Function (GOF)
No gain-of-function mutations have been reported for TUT7.
Dominant Negative (DN)
No dominant-negative mutations have been described for TUT7.
View complete mutation data：
Gene Ontology (GO)
| • RNA uridylyltransferase activity | • zinc ion binding |
| • nucleotidyltransferase activity | • RNA binding |
| • cytoplasm | • nucleus |
| • miRNA processing | • telomere maintenance |
Pathways
• miRNA biogenesis (let-7 uridylation)
• Telomere maintenance via telomerase
• RNA surveillance (3' end uridylation)
Protein Summary
TUT7 is a 1495-amino acid protein containing a CCHC-type zinc finger domain and a terminal uridylyltransferase (TUTase) domain. It localizes to both the cytoplasm and nucleus. The enzyme adds a short poly(U) tail to the 3' end of specific RNA substrates, including pre-let-7 miRNA and telomerase RNA component (TERC). This modification influences RNA stability, processing, and function. TUT7 interacts with other RNA-binding proteins and is regulated by post-translational modifications.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TUT7 Knockout HEK293 Cell Line | EDJ-KQ15990 | Human | 79670 | Details Get a Quote |
| TUT7 Knockout HeLa Cell Line | EDJ-KQ45824 | Human | 79670 | Details Get a Quote |
| TUT7 Knockout A-549 Cell Line | EDJ-KQ47040 | Human | 79670 | Details Get a Quote |
| TUT7 Knockout HCT 116 Cell Line | EDJ-KQ47041 | Human | 79670 | Details Get a Quote |
