TUSC2
Tumor Suppressor Candidate 2
Gene Information Card
| Symbol | TUSC2 |
|---|---|
| Full Name | Tumor Suppressor Candidate 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 11334 ncbi.nlm.nih.gov/gene/11334 |
| Ensembl ID | ENSG00000114737 |
| UniProt ID | O75896 |
| OMIM ID | 607052 |
| HGNC ID | 12448 |
| Aliases | FUS1, PDAP2, PAP, C3orf11 |
Description
TUSC2 (Tumor Suppressor Candidate 2) is a protein-coding gene located on chromosome 3p21.3. It functions as a tumor suppressor by inducing apoptosis and cell cycle arrest. The gene is frequently deleted or silenced in various cancers, including lung cancer. TUSC2 encodes a 110-amino acid protein that localizes to mitochondria and regulates calcium-mediated apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Loss of TUSC2 expression due to deletion or promoter methylation leads to reduced apoptosis and increased proliferation. | NCBI Gene, OMIM |
| Breast Cancer | TUSC2 downregulation is associated with poor prognosis and metastasis. | NCBI Gene, OMIM |
| Ovarian Cancer | TUSC2 deletion contributes to tumor progression. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 8.2 | Medium |
| Heart | 5.1 | Low |
| Brain | 2.3 | Low |
| Liver | 4.7 | Low |
| Kidney | 6.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung) | 12.5 | Cancer cell line |
| MCF7 (Breast) | 3.8 | Cancer cell line |
| HEK293 (Embryonic kidney) | 7.1 | Normal cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Rare | Unknown |
| c.82C>T | Nonsense | Rare | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., c.82C>T) produce truncated protein, reducing tumor suppressor activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • Apoptotic process | • Cell cycle arrest |
| • Mitochondrion | • Protein binding |
| • Calcium ion binding |
Pathways
• p53 signaling pathway
• Apoptosis
Protein Summary
The TUSC2 protein is a 110-amino acid mitochondrial protein that induces apoptosis through calcium-dependent mechanisms. It interacts with BCL2 family members and regulates cell cycle progression. Loss of TUSC2 expression is common in cancers, particularly lung cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TUSC2 Knockout HEK293 Cell Line | EDJ-KQ2694 | Human | 11334 | Details Get a Quote |
| TUSC2 Knockout A-549 Cell Line | EDJ-KQ23520 | Human | 11334 | Details Get a Quote |
| TUSC2 Knockout HCT 116 Cell Line | EDJ-KQ23521 | Human | 11334 | Details Get a Quote |
| TUSC2 Knockout HeLa Cell Line | EDJ-KQ23522 | Human | 11334 | Details Get a Quote |
