TSTD2
Thiosulfate Sulfurtransferase Domain Containing 2
Gene Information Card
| Symbol | TSTD2 |
|---|---|
| Full Name | Thiosulfate Sulfurtransferase Domain Containing 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q22.33 |
| NCBI Gene ID | 100128731 ncbi.nlm.nih.gov/gene/100128731 |
| Ensembl ID | ENSG00000204149 |
| UniProt ID | Q5VYJ5 |
| OMIM ID | 616240 |
| HGNC ID | 37276 |
| Aliases | MGC26733, TSTD2 |
Description
TSTD2 (Thiosulfate Sulfurtransferase Domain Containing 2) is a protein-coding gene located on chromosome 9q22.33. It encodes a thiosulfate sulfurtransferase enzyme involved in sulfur metabolism, catalyzing the transfer of sulfur from thiosulfate to cyanide or other acceptors. The gene is expressed in various tissues and may play a role in detoxification and mitochondrial function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 10.2 | Medium |
| Thyroid | 7.8 | Medium |
| Adrenal gland | 6.5 | Low |
| Liver | 4.3 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.1 | Moderate expression |
| HeLa | 6.4 | Low expression |
| K562 | 5.2 | Low expression |
| A549 | 4.7 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No loss-of-function variants characterized in ClinVar or COSMIC.
Gain of Function (GOF)
No gain-of-function variants characterized.
Dominant Negative (DN)
No dominant-negative variants characterized.
View complete mutation data：
Gene Ontology (GO)
| • thiosulfate sulfurtransferase activity | • sulfurtransferase activity |
| • mitochondrion |
Pathways
• Sulfur metabolism (KEGG: map00920)
Protein Summary
The TSTD2 protein is a thiosulfate sulfurtransferase localized to mitochondria. It catalyzes the conversion of thiosulfate and cyanide to sulfite and thiocyanate, contributing to cyanide detoxification and sulfur homeostasis. The protein contains a rhodanese-like domain and is expressed in multiple tissues with highest levels in testis and thyroid.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSTD2 Knockout HEK293 Cell Line | EDJ-KQ15964 | Human | 158427 | Details Get a Quote |
| TSTD2 Knockout A-549 Cell Line | EDJ-KQ46994 | Human | 158427 | Details Get a Quote |
| TSTD2 Knockout HCT 116 Cell Line | EDJ-KQ46995 | Human | 158427 | Details Get a Quote |
| TSTD2 Knockout HeLa Cell Line | EDJ-KQ46996 | Human | 158427 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
