TSTD1
Thiosulfate Sulfurtransferase Like Domain Containing 1
Gene Information Card
| Symbol | TSTD1 |
|---|---|
| Full Name | Thiosulfate Sulfurtransferase Like Domain Containing 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q42.12 |
| NCBI Gene ID | 100131187 ncbi.nlm.nih.gov/gene/100131187 |
| Ensembl ID | ENSG00000203710 |
| UniProt ID | Q8NFU3 |
| OMIM ID | 617822 |
| HGNC ID | 37238 |
| Aliases | MGC16384, FLJ25333 |
Description
TSTD1 encodes a protein containing a thiosulfate sulfurtransferase (TST) like domain. Sulfurtransferases catalyze the transfer of a sulfur atom from thiosulfate to cyanide, forming thiocyanate and sulfite. The specific biological function of TSTD1 is not fully characterized, but it is predicted to be involved in sulfur metabolism and cellular detoxification processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.1 | Low |
| Prostate | 2.8 | Low |
| Adrenal Gland | 2.5 | Low |
| Kidney | 2.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 1.5 | Low expression |
| HeLa | 1.2 | Low expression |
| K-562 | 0.8 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic mutations | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • sulfurtransferase activity (GO:0016783) | • cytoplasm (GO:0005737) |
Pathways
• Sulfur metabolism (Reactome: R-HSA-1614558)
Protein Summary
TSTD1 is a 297-amino acid protein with a predicted molecular weight of 33 kDa. It contains a rhodanese-like domain characteristic of sulfurtransferases. The protein is localized to the cytoplasm and may participate in sulfur transfer reactions, though its precise physiological role remains to be elucidated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSTD1 Knockout HEK293 Cell Line | EDJ-KQ11956 | Human | 100131187 | Details Get a Quote |
| TSTD1 Knockout HCT 116 Cell Line | EDJ-KQ40488 | Human | 100131187 | Details Get a Quote |
| TSTD1 Knockout HeLa Cell Line | EDJ-KQ40489 | Human | 100131187 | Details Get a Quote |
| TSTD1 Knockout A-549 Cell Line | EDJ-KQ69290 | Human | 100131187 | Details Get a Quote |
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