TSPY10: Testis-Specific Protein Y-Encoded 10 — A Y-Linked Gene with Restricted Testicular Expression
Explore the genomic context, expression profile, and functional significance of TSPY10, a Y-chromosome gene with testis-specific activity.
Gene Information Card
| Symbol | TSPY10 |
|---|---|
| Full Name | Testis-specific protein Y-encoded 10 |
| Gene Type | protein-coding |
| Chromosomal Location | Yp11.2 |
| NCBI Gene ID | 728358 ncbi.nlm.nih.gov/gene/728358 |
| Ensembl ID | ENSG00000205916 |
| UniProt ID | Q5J7B3 |
| OMIM ID | 400042 |
| HGNC ID | 30779 |
| Aliases | TSPY-like 10, TSPY10 |
Description
TSPY10 (testis-specific protein Y-encoded 10) is a protein-coding gene located on the short arm of the Y chromosome (Yp11.2). It belongs to the TSPY gene family, which is characterized by testis-specific expression and involvement in spermatogenesis. TSPY10 is one of several TSPY copies on the Y chromosome, and its expression is primarily restricted to testicular tissue, particularly in germ cells. The gene encodes a protein with a conserved nucleosome assembly protein (NAP) domain, suggesting a role in chromatin remodeling during spermatogenesis. TSPY10 has been implicated in male fertility and may also play a role in certain cancers, though its specific functions are still under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Male infertility | Altered expression or copy number variations of TSPY10 may disrupt spermatogenesis, contributing to reduced fertility. | Limited evidence; inferred from TSPY family function and expression studies. |
| Gonadoblastoma | TSPY genes, including TSPY10, are expressed in gonadoblastoma and may contribute to tumorigenesis via aberrant expression in dysgenetic gonads. | Evidence from TSPY family studies; specific TSPY10 data not yet established. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | High (nTPM not available) | Testis-specific expression, primarily in germ cells. |
| Other tissues | Not detected | No significant expression in somatic tissues. |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NT2/D1 (embryonal carcinoma) | Not specified | TSPY family expressed; TSPY10 not specifically quantified. |
| HeLa | Not detected | No expression in non-germline cell lines. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| Copy number variations (CNVs) | Structural variant | Variable in population | May affect gene dosage and spermatogenic efficiency. |
| Single nucleotide variants (SNVs) | Point mutation | Rare | Potential impact on protein function; not well characterized. |
Mutation functional classification
Loss of Function (LOF)
Loss-of-function mutations in TSPY10 are not well documented; however, reduced expression or copy number loss may impair spermatogenesis.
Gain of Function (GOF)
Gain-of-function alterations have not been reported; overexpression in certain cancers may contribute to tumor progression.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • nucleosome assembly | • chromatin remodeling |
| • DNA binding | • protein binding |
| • nucleus | • cytoplasm |
Pathways
• Spermatogenesis
• Chromatin organization
Protein Summary
The TSPY10 protein is a member of the TSPY family, characterized by a nucleosome assembly protein (NAP) domain. It is predominantly expressed in testicular germ cells and is thought to participate in chromatin remodeling during spermatogenesis. The protein may also be involved in cell cycle regulation and apoptosis. Its exact molecular interactions and downstream effects remain to be fully elucidated, but it is believed to play a role in male germ cell development and fertility.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPY10 Knockout HEK293 Cell Line | EDJ-KQ15962 | Human | 100289087 | Details Get a Quote |
| TSPY10 Knockout HeLa Cell Line | EDJ-KQ60880 | Human | 100289087 | Details Get a Quote |
| TSPY10 Knockout A-549 Cell Line | EDJ-KQ69353 | Human | 100289087 | Details Get a Quote |
| TSPY10 Knockout HCT 116 Cell Line | EDJ-KQ77707 | Human | 100289087 | Details Get a Quote |
