TSPAN2
Tetraspanin-2: A Transmembrane Protein Involved in Cell Signaling and Adhesion
Gene Information Card
| Symbol | TSPAN2 |
|---|---|
| Full Name | Tetraspanin 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p34.1 |
| NCBI Gene ID | 10100 ncbi.nlm.nih.gov/gene/10100 |
| Ensembl ID | ENSG00000116830 |
| UniProt ID | Q60636 |
| OMIM ID | 613133 |
| HGNC ID | 11853 |
| Aliases | TSPAN-2, NET-3, TSPAN2_HUMAN |
Description
TSPAN2 (tetraspanin 2) is a member of the tetraspanin family, a group of transmembrane proteins characterized by four conserved hydrophobic domains. Tetraspanins mediate signal transduction, cell adhesion, migration, and membrane organization. TSPAN2 is involved in the regulation of cell proliferation and differentiation, and its expression is altered in various cancers and inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression may affect cell adhesion and migration, promoting tumor progression | COSMIC, literature |
| Inflammatory diseases | Modulation of immune cell interactions via tetraspanin-enriched microdomains | Literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 10.3 | Medium |
| Testis | 8.7 | Low |
| Brain | 6.2 | Low |
| Liver | 3.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 15.2 | High expression |
| HeLa (cervical carcinoma) | 9.8 | Moderate expression |
| HEK293 (embryonic kidney) | 5.4 | Low expression |
| K562 (leukemia) | 2.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.1% | Unknown functional impact |
| c.345C>T (p.Ser115Leu) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TSPAN2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in TSPAN2.
Dominant Negative (DN)
No evidence of dominant-negative effects for TSPAN2.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005886 (GO:0005886) | • GO:0005887 (GO:0005887) |
| • GO:0007155 (GO:0007155) | • GO:0007165 (GO:0007165) |
| • GO:0016021 (GO:0016021) |
Pathways
• Tetraspanin-enriched microdomains
• Integrin signaling pathway
Protein Summary
Tetraspanin-2 is a 4-transmembrane domain protein that localizes to the plasma membrane and intracellular vesicles. It forms complexes with integrins and other tetraspanins, modulating cell adhesion, migration, and signal transduction. TSPAN2 is implicated in cancer progression and immune regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPAN2 Knockout HEK293 Cell Line | EDJ-KQ6897 | Human | 10100 | Details Get a Quote |
| TSPAN2 Knockout A-549 Cell Line | EDJ-KQ31513 | Human | 10100 | Details Get a Quote |
| TSPAN2 Knockout HeLa Cell Line | EDJ-KQ31514 | Human | 10100 | Details Get a Quote |
| TSPAN2 Knockout HCT 116 Cell Line | EDJ-KQ72260 | Human | 10100 | Details Get a Quote |
