TSPAN19
Tetraspanin 19: A member of the tetraspanin family involved in cell adhesion and signaling
Gene Information Card
| Symbol | TSPAN19 |
|---|---|
| Full Name | Tetraspanin 19 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q23.3 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000204310 |
| UniProt ID | Q8N6L1 |
| OMIM ID | 613466 |
| HGNC ID | 30758 |
| Aliases | NET-7, TSPAN-19, TSPAN19a, TSPAN19b |
Description
TSPAN19 (tetraspanin 19) is a protein-coding gene belonging to the tetraspanin family. Tetraspanins are transmembrane proteins that mediate signal transduction, cell adhesion, and cell motility. TSPAN19 is expressed in various tissues and may play a role in immune cell function and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | N/A | No curated evidence in OMIM or ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lung | 5.2 | Low |
| Spleen | 4.8 | Low |
| Kidney | 3.1 | Low |
| Brain | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 8.0 | Moderate expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.1 | Low expression |
| A549 | 1.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations in COSMIC or ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • cell adhesion (GO:0007155) |
Pathways
• No curated pathways in Reactome or KEGG
Protein Summary
TSPAN19 encodes a 4-transmembrane domain protein (tetraspanin) localized to the plasma membrane. It is involved in cell adhesion and signaling complexes, though its specific biological functions remain incompletely characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPAN19 Knockout HEK293 Cell Line | EDJ-KQ10420 | Human | 144448 | Details Get a Quote |
| TSPAN19 Knockout HeLa Cell Line | EDJ-KQ58510 | Human | 144448 | Details Get a Quote |
| TSPAN19 Knockout A-549 Cell Line | EDJ-KQ66998 | Human | 144448 | Details Get a Quote |
| TSPAN19 Knockout HCT 116 Cell Line | EDJ-KQ75398 | Human | 144448 | Details Get a Quote |
