TSPAN18
Tetraspanin 18: A Transmembrane Protein Involved in Cell Signaling and Adhesion
Gene Information Card
| Symbol | TSPAN18 |
|---|---|
| Full Name | Tetraspanin 18 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.5 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000204103 |
| UniProt ID | Q8N6P3 |
| OMIM ID | 615717 |
| HGNC ID | 33820 |
| Aliases | NET-6, TSPAN-18 |
Description
TSPAN18 (tetraspanin 18) is a protein-coding gene belonging to the tetraspanin family, characterized by four transmembrane domains. Tetraspanins are involved in cell adhesion, migration, signal transduction, and membrane organization. TSPAN18 is expressed in various tissues and has been implicated in cancer progression and other cellular processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Overexpression of TSPAN18 promotes cell proliferation and migration via activation of FAK signaling. | COSMIC, PubMed |
| Breast cancer | TSPAN18 expression is associated with poor prognosis and may enhance metastatic potential. | COSMIC, PubMed |
| Gastric cancer | Upregulation of TSPAN18 correlates with tumor invasion and lymph node metastasis. | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Breast | 8.3 | Low |
| Stomach | 10.1 | Medium |
| Lung | 6.7 | Low |
| Kidney | 9.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| MCF7 | 7.8 | Breast cancer cell line |
| AGS | 11.5 | Gastric cancer cell line |
| A549 | 5.9 | Lung cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.01% | Unknown functional impact; reported in COSMIC |
| c.341C>T (p.Pro114Leu) | Missense | <0.01% | Unknown functional impact; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TSPAN18.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
No evidence of dominant-negative mutations.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005886 (GO:0005886) | • GO:0005887 (GO:0005887) |
| • GO:0007155 (GO:0007155) | • GO:0016021 (GO:0016021) |
Pathways
• Integrin signaling pathway
• FAK signaling
Protein Summary
Tetraspanin 18 is a 4-transmembrane domain protein that localizes to the plasma membrane and intracellular vesicles. It interacts with integrins and other tetraspanins to regulate cell adhesion, migration, and signal transduction. Overexpression in several cancers suggests a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPAN18 Knockout HEK293 Cell Line | EDJ-KQ10557 | Human | 90139 | Details Get a Quote |
| TSPAN18 Knockout A-549 Cell Line | EDJ-KQ38010 | Human | 90139 | Details Get a Quote |
| TSPAN18 Knockout HeLa Cell Line | EDJ-KQ38012 | Human | 90139 | Details Get a Quote |
| TSPAN18 Knockout HCT 116 Cell Line | EDJ-KQ36709 | Human | 90139 | Details Get a Quote |
