TSPAN15
Tetraspanin 15: A Transmembrane Protein Involved in Cell Signaling and Cancer
Gene Information Card
| Symbol | TSPAN15 |
|---|---|
| Full Name | Tetraspanin 15 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q23.1 |
| NCBI Gene ID | 23555 ncbi.nlm.nih.gov/gene/23555 |
| Ensembl ID | ENSG00000120071 |
| UniProt ID | O95858 |
| OMIM ID | 613140 |
| HGNC ID | 20660 |
| Aliases | NET-7, TM4SF15 |
Description
TSPAN15 (tetraspanin 15) is a member of the tetraspanin family, characterized by four transmembrane domains. It functions as a cell surface protein involved in signal transduction, cell adhesion, and migration. TSPAN15 is implicated in cancer progression and immune modulation, with expression linked to poor prognosis in certain malignancies.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell proliferation and metastasis via integrin signaling | PMID: 31409832 |
| Lung cancer | Upregulation associated with enhanced tumor growth and invasion | PMID: 30348672 |
| Colorectal cancer | High expression correlates with advanced stage and poor survival | PMID: 29511321 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.3 | Medium |
| Breast | 8.7 | Low |
| Colon | 15.1 | Medium |
| Liver | 5.2 | Low |
| Kidney | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 14.5 | Moderate expression |
| A549 (lung cancer) | 18.2 | High expression |
| HCT116 (colorectal cancer) | 20.1 | High expression |
| HEK293 (embryonic kidney) | 6.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.500G>A (p.Arg167His) | Missense | <0.01% | Unknown functional impact |
| c.742C>T (p.Arg248Trp) | Missense | <0.01% | Reported in COSMIC; potential loss of function |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; some missense variants may impair protein stability.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • protein binding (GO:0005515) |
| • cell adhesion (GO:0007155) | • signal transduction (GO:0007165) |
Pathways
• Integrin signaling pathway (Reactome: R-HSA-446353)
• Cell surface interactions at the vascular wall (Reactome: R-HSA-202733)
Protein Summary
Tetraspanin 15 is a 4-transmembrane domain protein localized to the plasma membrane. It interacts with integrins and other tetraspanins to modulate cell adhesion, migration, and signaling. Overexpression in various cancers suggests a role in tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPAN15 Knockout HEK293 Cell Line | EDJ-KQ8068 | Human | 23555 | Details Get a Quote |
| TSPAN15 Knockout A-549 Cell Line | EDJ-KQ33893 | Human | 23555 | Details Get a Quote |
| TSPAN15 Knockout HCT 116 Cell Line | EDJ-KQ33894 | Human | 23555 | Details Get a Quote |
| TSPAN15 Knockout HeLa Cell Line | EDJ-KQ33895 | Human | 23555 | Details Get a Quote |
