TSPAN13
Tetraspanin 13: A Transmembrane Protein Involved in Cell Signaling and Cancer
Gene Information Card
| Symbol | TSPAN13 |
|---|---|
| Full Name | Tetraspanin 13 |
| Gene Type | Protein coding |
| Chromosomal Location | 7p21.1 |
| NCBI Gene ID | 27075 ncbi.nlm.nih.gov/gene/27075 |
| Ensembl ID | ENSG00000106537 |
| UniProt ID | O95857 |
| OMIM ID | 613139 |
| HGNC ID | 17763 |
| Aliases | NET-6, TM4SF13, TSPAN13 |
Description
TSPAN13 (tetraspanin 13) is a member of the tetraspanin family, characterized by four transmembrane domains. It is involved in cell adhesion, migration, and signal transduction. TSPAN13 is expressed in various tissues and has been implicated in cancer progression and immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Overexpression of TSPAN13 promotes cell proliferation and invasion through modulation of integrin signaling. | PMID: 23454898 |
| Breast cancer | TSPAN13 expression correlates with poor prognosis and may enhance metastatic potential. | PMID: 25642768 |
| Lung cancer | Upregulation of TSPAN13 is associated with tumor growth and resistance to apoptosis. | PMID: 27578530 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Prostate | 8.7 | Medium |
| Lung | 6.5 | Low |
| Breast | 5.2 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PC-3 (prostate cancer) | 15.4 | High expression |
| MCF-7 (breast cancer) | 9.8 | Medium expression |
| A549 (lung cancer) | 7.3 | Low expression |
| HEK293 (embryonic kidney) | 4.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.1% in COSMIC | Unknown functional effect |
| c.341C>T (p.Pro114Leu) | Missense | <0.1% in COSMIC | Unknown functional effect |
| c.452A>G (p.Asn151Ser) | Missense | <0.1% in COSMIC | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TSPAN13.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in TSPAN13.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in TSPAN13.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • cell adhesion (GO:0007155) | • signal transduction (GO:0007165) |
Pathways
• Integrin signaling pathway
• Cell adhesion molecules (CAMs)
Protein Summary
TSPAN13 is a 204-amino acid tetraspanin protein with four transmembrane domains. It localizes to the plasma membrane and participates in protein complexes that regulate cell adhesion, migration, and signaling. Its expression is altered in several cancers, suggesting a role in tumor biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPAN13 Knockout HEK293 Cell Line | EDJ-KQ8670 | Human | 27075 | Details Get a Quote |
| TSPAN13 Knockout A-549 Cell Line | EDJ-KQ34852 | Human | 27075 | Details Get a Quote |
| TSPAN13 Knockout HCT 116 Cell Line | EDJ-KQ34853 | Human | 27075 | Details Get a Quote |
| TSPAN13 Knockout HeLa Cell Line | EDJ-KQ34854 | Human | 27075 | Details Get a Quote |
