TSPAN11
Tetraspanin 11: A transmembrane protein with potential roles in cell adhesion and signaling
Gene Information Card
| Symbol | TSPAN11 |
|---|---|
| Full Name | tetraspanin 11 |
| Gene Type | protein-coding |
| Chromosomal Location | 12p11.21 |
| NCBI Gene ID | 23594 ncbi.nlm.nih.gov/gene/23594 |
| Ensembl ID | ENSG00000110934 |
| UniProt ID | Q8N2I9 |
| OMIM ID | 613267 |
| HGNC ID | 30713 |
| Aliases | NET-5, NET5, TSPAN-11 |
Description
TSPAN11 (tetraspanin 11) is a protein-coding gene that belongs to the tetraspanin family, characterized by four transmembrane domains. Tetraspanins are involved in cell adhesion, migration, and signal transduction by organizing multi-molecular complexes at the cell surface. TSPAN11 is expressed in various tissues and may play a role in immune cell function and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential role in tumor progression through modulation of cell adhesion and migration | Limited; expression changes observed in some cancers (COSMIC) |
| Immune-related disorders | Possible involvement in immune cell signaling | Inferred from family member functions; direct evidence lacking |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Testis | 8.2 | Low |
| Kidney | 6.1 | Low |
| Liver | 3.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 15.2 | Moderate expression |
| HEK 293 (embryonic kidney) | 7.8 | Low expression |
| K562 (leukemia) | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.1% | Unknown; likely benign |
| c.340C>T (p.Arg114Trp) | Missense | <0.1% | Unknown; likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • cell adhesion (GO:0007155) | • signal transduction (GO:0007165) |
Pathways
• Tetraspanin-enriched microdomains (TEMs) - inferred
Protein Summary
Tetraspanin 11 is a 4-transmembrane domain protein localized to the plasma membrane. It is involved in organizing membrane microdomains and facilitating interactions with integrins and other receptors, thereby modulating cell adhesion and signaling. Its precise biological functions remain under investigation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPAN11 Knockout HEK293 Cell Line | EDJ-KQ15955 | Human | 441631 | Details Get a Quote |
| TSPAN11 Knockout HeLa Cell Line | EDJ-KQ60436 | Human | 441631 | Details Get a Quote |
| TSPAN11 Knockout A-549 Cell Line | EDJ-KQ68904 | Human | 441631 | Details Get a Quote |
| TSPAN11 Knockout HCT 116 Cell Line | EDJ-KQ77265 | Human | 441631 | Details Get a Quote |
