TSPAN1: Tetraspanin-1 – A Transmembrane Protein with Roles in Cell Signaling and Cancer
Comprehensive biomedical overview of TSPAN1, including gene structure, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | TSPAN1 |
|---|---|
| Full Name | Tetraspanin 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p34.1 |
| NCBI Gene ID | 10103 ncbi.nlm.nih.gov/gene/10103 |
| Ensembl ID | ENSG00000117472 |
| UniProt ID | O60635 |
| OMIM ID | 613133 |
| HGNC ID | 11857 |
| Aliases | NET-1, TM4SF1, TSPAN-1, TSPAN1 |
Description
TSPAN1 (tetraspanin 1) is a member of the tetraspanin family, characterized by four transmembrane domains. It functions as a cell surface protein involved in cell adhesion, migration, and signal transduction. TSPAN1 is implicated in cancer progression, particularly in gastric, colorectal, and pancreatic cancers, where it may promote tumor growth and metastasis. It also plays roles in immune cell activation and angiogenesis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Overexpression promotes cell proliferation and invasion via activation of PI3K/Akt signaling | PMID: 25695682 |
| Colorectal cancer | Upregulation correlates with poor prognosis and enhanced metastatic potential | PMID: 27158355 |
| Pancreatic ductal adenocarcinoma | High expression associated with tumor progression and reduced survival | PMID: 29351287 |
| Hepatocellular carcinoma | TSPAN1 silencing reduces cell migration and invasion in vitro | PMID: 30328014 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Stomach | 18.3 | High |
| Colon | 15.7 | High |
| Pancreas | 9.8 | Medium |
| Liver | 6.2 | Low |
| Breast | 8.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 14.2 | High expression |
| MKN45 (gastric cancer) | 22.1 | Very high expression |
| HCT116 (colorectal cancer) | 19.5 | High expression |
| PANC-1 (pancreatic cancer) | 11.3 | Medium expression |
| HepG2 (hepatocellular carcinoma) | 7.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.365G>A (p.Arg122His) | Missense | <0.1% in COSMIC | Unknown functional effect |
| c.478C>T (p.Arg160Trp) | Missense | <0.1% in COSMIC | Unknown functional effect |
| c.602A>G (p.Asn201Ser) | Missense | <0.1% in COSMIC | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in TSPAN1.
Gain of Function (GOF)
Overexpression in multiple cancers suggests potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
No dominant-negative mutations described for TSPAN1.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane (GO:0005886) | • integral component of membrane (GO:0016021) |
| • cell adhesion (GO:0007155) | • negative regulation of cell proliferation (GO:0008285) |
| • cell differentiation (GO:0030154) | • negative regulation of apoptotic process (GO:0043066) |
Pathways
• PI3K-Akt signaling pathway (Reactome: R-HSA-1257604)
• Integrin signaling pathway (Reactome: R-HSA-354192)
• Cell surface interactions at the vascular wall (Reactome: R-HSA-202733)
Protein Summary
Tetraspanin-1 (TSPAN1) is a 241-amino acid transmembrane protein with four hydrophobic domains. It localizes to the plasma membrane and forms complexes with integrins and other tetraspanins, modulating cell adhesion and signaling. TSPAN1 is frequently overexpressed in epithelial cancers and is considered a potential biomarker and therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSPAN1 Knockout HEK293 Cell Line | EDJ-KQ6898 | Human | 10103 | Details Get a Quote |
| TSPAN12 Knockout HEK293 Cell Line | EDJ-KQ8066 | Human | 23554 | Details Get a Quote |
| TSPAN15 Knockout HEK293 Cell Line | EDJ-KQ8068 | Human | 23555 | Details Get a Quote |
| TSPAN17 Knockout HEK293 Cell Line | EDJ-KQ8491 | Human | 26262 | Details Get a Quote |
| TSPAN16 Knockout HEK293 Cell Line | EDJ-KQ8549 | Human | 26526 | Details Get a Quote |
| TSPAN13 Knockout HEK293 Cell Line | EDJ-KQ8670 | Human | 27075 | Details Get a Quote |
| TSPAN14 Knockout HEK293 Cell Line | EDJ-KQ9729 | Human | 81619 | Details Get a Quote |
| TSPAN10 Knockout HEK293 Cell Line | EDJ-KQ9919 | Human | 83882 | Details Get a Quote |
| TSPAN19 Knockout HEK293 Cell Line | EDJ-KQ10420 | Human | 144448 | Details Get a Quote |
| TSPAN18 Knockout HEK293 Cell Line | EDJ-KQ10557 | Human | 90139 | Details Get a Quote |
| TSPAN11 Knockout HEK293 Cell Line | EDJ-KQ15955 | Human | 441631 | Details Get a Quote |
| TSPAN18 Knockout A-549 Cell Line | EDJ-KQ38010 | Human | 90139 | Details Get a Quote |
| TSPAN18 Knockout HeLa Cell Line | EDJ-KQ38012 | Human | 90139 | Details Get a Quote |
| TSPAN1 Knockout A-549 Cell Line | EDJ-KQ31515 | Human | 10103 | Details Get a Quote |
| TSPAN1 Knockout HCT 116 Cell Line | EDJ-KQ31516 | Human | 10103 | Details Get a Quote |
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