TSNAX: Translin-Associated Factor X
A gene encoding a protein involved in RNA metabolism, DNA repair, and chromosomal translocation-associated processes.
Gene Information Card
| Symbol | TSNAX |
|---|---|
| Full Name | Translin-Associated Factor X |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q42.2 |
| NCBI Gene ID | 7257 ncbi.nlm.nih.gov/gene/7257 |
| Ensembl ID | ENSG00000116285 |
| UniProt ID | Q99598 |
| OMIM ID | 602979 |
| HGNC ID | 12379 |
| Aliases | TRAX, C1orf23, TSNAX1 |
Description
TSNAX (Translin-Associated Factor X) encodes a protein that forms a heteromeric complex with translin (TSN). This complex is involved in RNA metabolism, including mRNA transport and translation, as well as DNA repair and chromosomal translocation events. The gene is located on chromosome 1q42.2 and is widely expressed.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association confirmed | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Lung | 6.1 | Low |
| Liver | 4.3 | Low |
| Heart | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.1 | RNA-seq data from GTEx |
| HeLa | 7.8 | RNA-seq data from GTEx |
| K562 | 6.5 | RNA-seq data from GTEx |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Synonymous | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • DNA binding (GO:0003677) |
| • protein heterodimerization activity (GO:0046982) | • cytoplasm (GO:0005737) |
| • nucleus (GO:0005634) |
Pathways
• Translin-TRAX complex pathway (Reactome: R-HSA-6803520)
• RNA transport (KEGG: hsa03013)
Protein Summary
The TSNAX protein (also known as TRAX) is a 290-amino acid protein that interacts with translin (TSN) to form a heteromeric complex. This complex binds single-stranded DNA and RNA, playing roles in RNA metabolism, DNA repair, and chromosomal translocation. The protein is localized in both the cytoplasm and nucleus.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TSNAX Knockout HEK293 Cell Line | EDJ-KQ5971 | Human | 7257 | Details Get a Quote |
| TSNAXIP1 Knockout HEK293 Cell Line | EDJ-KQ15954 | Human | 55815 | Details Get a Quote |
| TSNAXIP1 Knockout A-549 Cell Line | EDJ-KQ46982 | Human | 55815 | Details Get a Quote |
| TSNAXIP1 Knockout HCT 116 Cell Line | EDJ-KQ46983 | Human | 55815 | Details Get a Quote |
| TSNAX Knockout A-549 Cell Line | EDJ-KQ28264 | Human | 7257 | Details Get a Quote |
| TSNAX Knockout HCT 116 Cell Line | EDJ-KQ29540 | Human | 7257 | Details Get a Quote |
| TSNAX Knockout HeLa Cell Line | EDJ-KQ29541 | Human | 7257 | Details Get a Quote |
| TSNAXIP1 Knockout HeLa Cell Line | EDJ-KQ56637 | Human | 55815 | Details Get a Quote |
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