TRPC7: Transient Receptor Potential Cation Channel Subfamily C Member 7
A calcium-permeable cation channel involved in receptor-operated calcium entry and cellular signaling.
Gene Information Card
| Symbol | TRPC7 |
|---|---|
| Full Name | Transient Receptor Potential Cation Channel Subfamily C Member 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q31.1 |
| NCBI Gene ID | 57113 ncbi.nlm.nih.gov/gene/57113 |
| Ensembl ID | ENSG00000169085 |
| UniProt ID | Q9HCX4 |
| OMIM ID | 614392 |
| HGNC ID | 12337 |
| Aliases | TRP7, FLJ42952 |
Description
TRPC7 (Transient Receptor Potential Cation Channel Subfamily C Member 7) encodes a member of the transient receptor potential (TRP) family of ion channels. The protein forms a non-selective, calcium-permeable cation channel that is activated by diacylglycerol (DAG) and phospholipase C (PLC)-coupled receptors. TRPC7 is involved in receptor-operated calcium entry (ROCE) and plays roles in cellular signaling, including regulation of cell proliferation and apoptosis. The gene is located on chromosome 5q31.1 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 3.2 | Low |
| Heart | 1.8 | Low |
| Kidney | 2.5 | Low |
| Liver | 1.1 | Not detected |
| Lung | 2.0 | Low |
| Testis | 4.5 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 5.0 | Moderate expression in recombinant systems |
| SH-SY5Y | 3.8 | Neuronal cell line |
| HeLa | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No documented loss-of-function mutations in ClinVar or COSMIC.
Gain of Function (GOF)
No documented gain-of-function mutations in ClinVar or COSMIC.
Dominant Negative (DN)
No documented dominant-negative mutations in ClinVar or COSMIC.
View complete mutation data：
Gene Ontology (GO)
| • GO:0005262 (GO:0005262) | • GO:0005515 (GO:0005515) |
| • GO:0005886 (GO:0005886) | • GO:0006816 (GO:0006816) |
| • GO:0016021 (GO:0016021) | • GO:0070588 (GO:0070588) |
Pathways
• Receptor-operated calcium entry (ROCE)
• Phospholipase C (PLC) signaling pathway
• Calcium signaling pathway
Protein Summary
TRPC7 is a 862-amino acid protein with six transmembrane domains, forming a non-selective cation channel permeable to calcium. It is activated by diacylglycerol (DAG) independently of protein kinase C. The channel contributes to receptor-operated calcium entry (ROCE) and is involved in cellular processes such as proliferation and apoptosis. Expression is detected in brain, testis, and other tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRPC7 Knockout HEK293 Cell Line | EDJ-KQ15156 | Human | 57113 | Details Get a Quote |
| TRPC7 Knockout HeLa Cell Line | EDJ-KQ56805 | Human | 57113 | Details Get a Quote |
| TRPC7 Knockout A-549 Cell Line | EDJ-KQ65311 | Human | 57113 | Details Get a Quote |
| TRPC7 Knockout HCT 116 Cell Line | EDJ-KQ73751 | Human | 57113 | Details Get a Quote |
