TRPC5 Opposite Strand (TRPC5OS)
A long non-coding RNA gene with potential regulatory roles in cellular signaling and disease.
Gene Information Card
| Symbol | TRPC5OS |
|---|---|
| Full Name | TRPC5 Opposite Strand |
| Gene Type | non-coding RNA (lncRNA) |
| Chromosomal Location | Xq23 |
| NCBI Gene ID | 100506658 ncbi.nlm.nih.gov/gene/100506658 |
| Ensembl ID | ENSG00000224389 |
| UniProt ID | N/A (non-coding) |
| OMIM ID | N/A |
| HGNC ID | HGNC:48880 |
| Aliases | TRPC5-AS1, TRPC5 antisense RNA 1 |
Description
TRPC5OS (TRPC5 Opposite Strand) is a long non-coding RNA (lncRNA) gene located on the X chromosome (Xq23). It is transcribed from the opposite strand of the TRPC5 gene, which encodes a transient receptor potential cation channel. The function of TRPC5OS is not fully characterized, but lncRNAs in this region may regulate TRPC5 expression or participate in cellular signaling pathways. Limited evidence suggests potential involvement in cancer and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Potential dysregulation of TRPC5OS may affect TRPC5 expression, influencing calcium signaling and cell proliferation. | Indirect evidence from expression studies; no direct causal link established. |
| Neurological disorders | Possible modulation of TRPC5 channel activity, which is involved in neuronal excitability. | Hypothetical based on genomic proximity; no direct clinical evidence. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.2 | Not detected |
| Brain | 0.1 | Not detected |
| Lung | 0.1 | Not detected |
| Kidney | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.0 | Not detected |
| K562 | 0.0 | Not detected |
| HEK293 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not applicable; no protein product.
Gain of Function (GOF)
Not applicable; no protein product.
Dominant Negative (DN)
Not applicable; no protein product.
View complete mutation data：
Protein Summary
TRPC5OS does not encode a protein; it is a long non-coding RNA. Its functional role is likely regulatory, possibly influencing the expression of the neighboring TRPC5 gene.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRPC5OS Knockout HEK293 Cell Line | EDJ-KQ15948 | Human | 100329135 | Details Get a Quote |
| TRPC5OS Knockout HeLa Cell Line | EDJ-KQ60887 | Human | 100329135 | Details Get a Quote |
| TRPC5OS Knockout A-549 Cell Line | EDJ-KQ69361 | Human | 100329135 | Details Get a Quote |
| TRPC5OS Knockout HCT 116 Cell Line | EDJ-KQ77715 | Human | 100329135 | Details Get a Quote |
