TRNAU1AP Gene
tRNA selenocysteine 1 associated protein 1
Gene Information Card
| Symbol | TRNAU1AP |
|---|---|
| Full Name | tRNA selenocysteine 1 associated protein 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.13 |
| NCBI Gene ID | 54952 ncbi.nlm.nih.gov/gene/54952 |
| Ensembl ID | ENSG00000117500 |
| UniProt ID | Q9H0C8 |
| OMIM ID | 610991 |
| HGNC ID | 25713 |
| Aliases | SELTP, SECp43, TRNAU1AP1 |
Description
TRNAU1AP (tRNA selenocysteine 1 associated protein 1) encodes a protein that binds to selenocysteine tRNA and is involved in selenoprotein synthesis. It plays a role in the incorporation of selenocysteine into proteins, a process essential for antioxidant defense and thyroid hormone metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
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Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|
Cell Line Expression
| Cell Line | nTPM | Notes |
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Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|
Mutation functional classification
Loss of Function (LOF)
Gain of Function (GOF)
Dominant Negative (DN)
View complete mutation data：
Protein Summary
The TRNAU1AP protein, also known as SECp43, is a 43 kDa RNA-binding protein that specifically interacts with selenocysteine tRNA (tRNA[Ser]Sec). It facilitates the efficient recoding of the UGA stop codon as selenocysteine, thereby supporting the synthesis of selenoproteins. The protein is localized in the nucleus and cytoplasm.
Related Services
Related Products
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|---|---|---|---|---|
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