TRMT9B
tRNA methyltransferase 9B (putative)
Gene Information Card
| Symbol | TRMT9B |
|---|---|
| Full Name | tRNA methyltransferase 9B (putative) |
| Gene Type | protein-coding |
| Chromosomal Location | 8q24.13 |
| NCBI Gene ID | 158234 ncbi.nlm.nih.gov/gene/158234 |
| Ensembl ID | ENSG00000178568 |
| UniProt ID | Q7Z2T5 |
| OMIM ID | 616975 |
| HGNC ID | 26938 |
| Aliases | C8orf32, FLJ39005, MGC138290 |
Description
TRMT9B (tRNA methyltransferase 9B) is a protein-coding gene located on chromosome 8q24.13. It encodes a putative tRNA methyltransferase involved in post-transcriptional modification of tRNAs, specifically methylation. The gene is expressed in various tissues and may play a role in cellular translation regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 6.1 | Low |
| Heart | 4.3 | Low |
| Kidney | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.1 | Moderate expression |
| HeLa | 7.5 | Low expression |
| K562 | 5.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • tRNA methyltransferase activity (GO:0008175) | • tRNA methylation (GO:0030488) |
| • cytoplasm (GO:0005737) |
Pathways
• tRNA modification in the nucleus and cytosol
Protein Summary
The TRMT9B protein is a putative tRNA methyltransferase that likely catalyzes the methylation of specific tRNA residues. Its exact substrate and biological role remain under investigation, but it is predicted to localize to the cytoplasm and contribute to tRNA maturation and translation fidelity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRMT9B Knockout HEK293 Cell Line | EDJ-KQ15943 | Human | 57604 | Details Get a Quote |
| TRMT9B Knockout HeLa Cell Line | EDJ-KQ56880 | Human | 57604 | Details Get a Quote |
| TRMT9B Knockout A-549 Cell Line | EDJ-KQ65391 | Human | 57604 | Details Get a Quote |
| TRMT9B Knockout HCT 116 Cell Line | EDJ-KQ73828 | Human | 57604 | Details Get a Quote |
