TRMT6: tRNA Methyltransferase 6
A key component of the tRNA methyltransferase complex involved in N1-methyladenosine modification of tRNA
Gene Information Card
| Symbol | TRMT6 |
|---|---|
| Full Name | tRNA methyltransferase 6 (N1-methyladenine) |
| Gene Type | protein-coding |
| Chromosomal Location | 20p12.3 |
| NCBI Gene ID | 51605 ncbi.nlm.nih.gov/gene/51605 |
| Ensembl ID | ENSG00000101204 |
| UniProt ID | Q9Y2Z0 |
| OMIM ID | 616209 |
| HGNC ID | 26020 |
| Aliases | GCD10, TRM6, CGI-09, MST050 |
Description
TRMT6 encodes a subunit of the tRNA methyltransferase complex that catalyzes the formation of N1-methyladenosine (m1A) at position 58 of tRNA. This modification is essential for tRNA stability and proper translation. The protein forms a heterodimer with TRMT61A to exert its methyltransferase activity.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered m1A modification affects tRNA stability and translation efficiency, potentially promoting oncogenic protein synthesis | COSMIC; literature reports |
| Intellectual disability (candidate) | Disruption of tRNA modification may impair neuronal translation | ClinVar; limited evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Thyroid | 10.2 | Medium |
| Adrenal gland | 9.8 | Medium |
| Liver | 8.1 | Medium |
| Brain | 6.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | High expression |
| HeLa | 12.1 | Moderate expression |
| K562 | 9.4 | Moderate expression |
| HepG2 | 8.7 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Unknown functional impact |
| c.1015G>A (p.Gly339Arg) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • RNA binding (GO:0003723) | • tRNA methyltransferase activity (GO:0008175) |
| • cytoplasm (GO:0005737) | • nucleus (GO:0005634) |
| • tRNA methylation (GO:0030488) | • tRNA modification (GO:0006400) |
Pathways
• tRNA modification in the nucleus and cytoplasm
• m1A modification at position 58 of tRNA
Protein Summary
TRMT6 is a 45 kDa protein that forms a complex with TRMT61A to catalyze N1-methyladenosine formation at position 58 of tRNA. This modification is critical for tRNA folding, stability, and efficient translation. The protein contains a conserved methyltransferase domain and is expressed in multiple tissues, with highest levels in testis and thyroid.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRMT61B Knockout HEK293 Cell Line | EDJ-KQ15946 | Human | 55006 | Details Get a Quote |
| TRMT61B Knockout A-549 Cell Line | EDJ-KQ46968 | Human | 55006 | Details Get a Quote |
| TRMT61B Knockout HCT 116 Cell Line | EDJ-KQ46969 | Human | 55006 | Details Get a Quote |
| TRMT61B Knockout HeLa Cell Line | EDJ-KQ46970 | Human | 55006 | Details Get a Quote |
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