TRIM77
Tripartite Motif Containing 77
Gene Information Card
| Symbol | TRIM77 |
|---|---|
| Full Name | Tripartite Motif Containing 77 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q29 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000204103 |
| UniProt ID | A6NGE7 |
| OMIM ID | - |
| HGNC ID | 37272 |
| Aliases | - |
Description
TRIM77 (tripartite motif containing 77) is a protein-coding gene located on chromosome 3q29. It belongs to the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc finger, and coiled-coil region. TRIM proteins are involved in diverse cellular processes including innate immunity, ubiquitination, and antiviral defense. As of the current data, specific functional characterization and disease associations for TRIM77 are limited in major curated databases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | - | - |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.3 | Low |
| Thyroid | 0.2 | Low |
| Adrenal gland | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No curated cell line expression data | - | - |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated mutations in COSMIC or ClinVar | - | - | - |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • metal ion binding (GO:0046872) |
Protein Summary
The TRIM77 protein (UniProt A6NGE7) is a member of the TRIM family, containing a RING-type zinc finger domain, B-box-type zinc finger, and a coiled-coil region. Its specific biological function remains poorly characterized, but it is predicted to participate in protein ubiquitination and cellular defense mechanisms based on family homology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM77 Knockout HEK293 Cell Line | EDJ-KQ15934 | Human | 390231 | Details Get a Quote |
| TRIM77 Knockout HeLa Cell Line | EDJ-KQ60159 | Human | 390231 | Details Get a Quote |
| TRIM77 Knockout A-549 Cell Line | EDJ-KQ68620 | Human | 390231 | Details Get a Quote |
| TRIM77 Knockout HCT 116 Cell Line | EDJ-KQ76989 | Human | 390231 | Details Get a Quote |
