TRIM75: Tripartite Motif Containing 75
A TRIM family protein with potential roles in ubiquitination and antiviral defense.
Gene Information Card
| Symbol | TRIM75 |
|---|---|
| Full Name | Tripartite Motif Containing 75 |
| Gene Type | Protein coding |
| Chromosomal Location | 4q32.3 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000204624 |
| UniProt ID | A6NHR9 |
| OMIM ID | Not assigned |
| HGNC ID | 37265 |
| Aliases | MGC26717, FLJ40365 |
Description
TRIM75 (Tripartite Motif Containing 75) is a protein-coding gene belonging to the tripartite motif (TRIM) family. TRIM proteins are characterized by a conserved RBCC (RING finger, B-box, coiled-coil) domain and are involved in diverse cellular processes including innate immunity, ubiquitination, and antiviral responses. TRIM75 is located on chromosome 4q32.3 and is expressed in multiple tissues. Its specific biological functions remain under investigation, but it is predicted to participate in protein ubiquitination and may play a role in host defense against viruses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No curated disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.1 | Low |
| Prostate | 2.8 | Low |
| Lung | 2.0 | Low |
| Breast | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.0 | Embryonic kidney |
| HeLa | 3.5 | Cervical cancer |
| K562 | 2.1 | Leukemia |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • zinc ion binding (GO:0008270) |
| • metal ion binding (GO:0046872) | • ubiquitin protein ligase activity (GO:0061630) |
Pathways
• No curated pathways
Protein Summary
The TRIM75 protein (UniProt A6NHR9) is a 493-amino acid polypeptide containing a RING-type zinc finger domain, two B-box domains, and a coiled-coil region, characteristic of the TRIM family. It is predicted to function as an E3 ubiquitin-protein ligase, mediating ubiquitination of target proteins. Subcellular localization is likely cytoplasmic. The protein may be involved in antiviral innate immunity through ubiquitination of viral components or host signaling molecules.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM75 Knockout HEK293 Cell Line | EDJ-KQ15933 | Human | 391714 | Details Get a Quote |
| TRIM75 Knockout A-549 Cell Line | EDJ-KQ46942 | Human | 391714 | Details Get a Quote |
| TRIM75 Knockout HCT 116 Cell Line | EDJ-KQ46943 | Human | 391714 | Details Get a Quote |
| TRIM75 Knockout HeLa Cell Line | EDJ-KQ46944 | Human | 391714 | Details Get a Quote |
