TRIM74 Gene - Tripartite Motif Containing 74
Comprehensive guide to TRIM74: genomic location, expression, function, and clinical significance.
Gene Information Card
| Symbol | TRIM74 |
|---|---|
| Full Name | tripartite motif containing 74 |
| Gene Type | gene with protein product |
| Chromosomal Location | 7q11.23 |
| NCBI Gene ID | 378108 ncbi.nlm.nih.gov/gene/378108 |
| Ensembl ID | ENSG00000155428 |
| UniProt ID | Q86UV6 |
| OMIM ID | 612550 |
| HGNC ID | HGNC:17453 |
| Aliases | MGC45440, TRIM50C |
Description
TRIM74 (tripartite motif containing 74) is a protein-coding gene located on chromosome 7q11.23. It belongs to the tripartite motif (TRIM) family, characterized by a RING finger, B-box, and coiled-coil domains. The encoded protein may play a role in ubiquitination and protein degradation. TRIM74 is part of a cluster of TRIM genes in the Williams-Beuren syndrome region, but its specific function is not fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Disease | Mechanism | Evidence |
| No specific disease association | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Tissue | nTPM | Level |
| Testis | 5.2 | Low |
| Thyroid | 4.1 | Low |
| Adrenal gland | 3.8 | Low |
| Prostate | 3.5 | Low |
| Fallopian tube | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Cell Line | nTPM | Notes |
| HEK 293 | 2.1 | Low expression |
| HeLa | 1.8 | Low expression |
| K562 | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| Variant | Type | Frequency | Effect |
| No clinically significant variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available; no loss-of-function mutations have been characterized.
Gain of Function (GOF)
No data available; no gain-of-function mutations have been characterized.
Dominant Negative (DN)
No data available; no dominant-negative mutations have been characterized.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • zinc ion binding |
| • ubiquitin-protein transferase activity |
Pathways
• Ubiquitin mediated proteolysis (potential)
Protein Summary
The TRIM74 protein is a member of the TRIM family, which typically function as E3 ubiquitin ligases. It contains a RING finger domain, B-box domains, and a coiled-coil region. The exact function of TRIM74 is not well understood, but it may be involved in protein ubiquitination and degradation. It is expressed at low levels in various tissues, with highest expression in testis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM74 Knockout HEK293 Cell Line | EDJ-KQ15932 | Human | 378108 | Details Get a Quote |
| TRIM74 Knockout HeLa Cell Line | EDJ-KQ59942 | Human | 378108 | Details Get a Quote |
| TRIM74 Knockout A-549 Cell Line | EDJ-KQ68403 | Human | 378108 | Details Get a Quote |
| TRIM74 Knockout HCT 116 Cell Line | EDJ-KQ76781 | Human | 378108 | Details Get a Quote |
