TRIM73 Gene - Tripartite Motif Containing 73
A member of the TRIM protein family involved in innate immunity and ubiquitination.
Gene Information Card
| Symbol | TRIM73 |
|---|---|
| Full Name | Tripartite Motif Containing 73 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q11.23 |
| NCBI Gene ID | 100129924 ncbi.nlm.nih.gov/gene/100129924 |
| Ensembl ID | ENSG00000205853 |
| UniProt ID | Q6PJ69 |
| OMIM ID | 616761 |
| HGNC ID | 37231 |
| Aliases | RNF118, TRIM73L |
Description
TRIM73 (tripartite motif containing 73) is a protein-coding gene belonging to the TRIM/RBCC family. The encoded protein contains a RING finger domain, B-box zinc finger, and coiled-coil region, and is involved in ubiquitination and innate immune signaling. TRIM73 is located on chromosome 7q11.23 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No direct evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Thyroid | 3.8 | Low |
| Prostate | 2.9 | Low |
| Adrenal gland | 2.5 | Low |
| Lung | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| K562 | 0.3 | Low expression |
| HeLa | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • zinc ion binding (GO:0008270) |
| • metal ion binding (GO:0046872) | • ubiquitin protein ligase activity (GO:0061630) |
Pathways
• No curated pathways available
Protein Summary
The TRIM73 protein (UniProt Q6PJ69) is a 374-amino acid member of the tripartite motif family. It contains a RING-type zinc finger domain (residues 15-57), two B-box-type zinc fingers (residues 93-136 and 141-183), and a coiled-coil region (residues 194-233). The RING domain mediates E3 ubiquitin ligase activity. Expression is low in most tissues, with highest levels in testis and thyroid.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM73 Knockout HEK293 Cell Line | EDJ-KQ15931 | Human | 375593 | Details Get a Quote |
| TRIM73 Knockout A-549 Cell Line | EDJ-KQ46940 | Human | 375593 | Details Get a Quote |
| TRIM73 Knockout HCT 116 Cell Line | EDJ-KQ49162 | Human | 375593 | Details Get a Quote |
| TRIM73 Knockout HeLa Cell Line | EDJ-KQ59927 | Human | 375593 | Details Get a Quote |
