TRIM7: Tripartite Motif Containing 7
A RING-type E3 ubiquitin ligase involved in innate immunity, viral restriction, and cancer signaling.
Gene Information Card
| Symbol | TRIM7 |
|---|---|
| Full Name | Tripartite Motif Containing 7 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 81786 ncbi.nlm.nih.gov/gene/81786 |
| Ensembl ID | ENSG00000164330 |
| UniProt ID | Q9C029 |
| OMIM ID | 605759 |
| HGNC ID | 16276 |
| Aliases | GNIP, RNF90, SCAF10 |
Description
TRIM7 (Tripartite Motif Containing 7) encodes a member of the tripartite motif (TRIM) family. The protein contains a RING finger domain, B-box, and coiled-coil region, and functions as an E3 ubiquitin ligase. TRIM7 is involved in innate immune responses, viral restriction (e.g., norovirus, SARS-CoV-2), and modulation of signaling pathways including NF-κB and mTOR. It also plays a role in cell proliferation and has been implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | TRIM7 overexpression promotes cell proliferation and invasion via ubiquitination of p53 and activation of AKT signaling. | PMID: 31525673 |
| Hepatocellular carcinoma | TRIM7 acts as a tumor suppressor by promoting degradation of the oncoprotein c-Myc. | PMID: 32047112 |
| Viral infection (Norovirus) | TRIM7 restricts norovirus replication by ubiquitinating the viral NS6/7 protease. | PMID: 33357406 |
| Viral infection (SARS-CoV-2) | TRIM7 ubiquitinates the SARS-CoV-2 envelope protein, limiting viral assembly. | PMID: 34079125 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Lymph node | 8.3 | Low |
| Spleen | 7.1 | Low |
| Bone marrow | 6.8 | Low |
| Lung | 5.2 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Highest expression in kidney-derived cell line |
| HeLa | 9.8 | Moderate expression |
| HepG2 | 6.5 | Low expression |
| A549 | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.511C>T (p.Arg171Trp) | Missense | <0.01% | Unknown; located in coiled-coil domain |
| c.763G>A (p.Glu255Lys) | Missense | <0.01% | Unknown; located in B-box domain |
| c.1000_1001insA (p.Thr334Asnfs*12) | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., p.Thr334Asnfs*12) are predicted to cause premature truncation and loss of E3 ligase activity.
Gain of Function (GOF)
Not well characterized; overexpression in colorectal cancer suggests potential gain-of-function in oncogenic contexts.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• mTOR signaling pathway (Reactome: R-HSA-165159)
Protein Summary
TRIM7 is a 574-amino acid protein with a molecular weight of approximately 65 kDa. It contains an N-terminal RING finger domain (required for E3 ligase activity), two B-box domains, a coiled-coil region, and a C-terminal PRY/SPRY domain. The protein localizes to the cytoplasm and nucleus. TRIM7 mediates ubiquitination of target proteins such as p53, c-Myc, and viral proteases, thereby regulating cell cycle, apoptosis, and antiviral responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM71 Knockout HEK293 Cell Line | EDJ-KQ9267 | Human | 131405 | Details Get a Quote |
| TRIM7 Knockout HEK293 Cell Line | EDJ-KQ9744 | Human | 81786 | Details Get a Quote |
| TRIM72 Knockout HEK293 Cell Line | EDJ-KQ15930 | Human | 493829 | Details Get a Quote |
| TRIM73 Knockout HEK293 Cell Line | EDJ-KQ15931 | Human | 375593 | Details Get a Quote |
| TRIM74 Knockout HEK293 Cell Line | EDJ-KQ15932 | Human | 378108 | Details Get a Quote |
| TRIM75 Knockout HEK293 Cell Line | EDJ-KQ15933 | Human | 391714 | Details Get a Quote |
| TRIM77 Knockout HEK293 Cell Line | EDJ-KQ15934 | Human | 390231 | Details Get a Quote |
| TRIM72 Knockout HCT 116 Cell Line | EDJ-KQ46939 | Human | 493829 | Details Get a Quote |
| TRIM73 Knockout A-549 Cell Line | EDJ-KQ46940 | Human | 375593 | Details Get a Quote |
| TRIM75 Knockout A-549 Cell Line | EDJ-KQ46942 | Human | 391714 | Details Get a Quote |
| TRIM75 Knockout HCT 116 Cell Line | EDJ-KQ46943 | Human | 391714 | Details Get a Quote |
| TRIM75 Knockout HeLa Cell Line | EDJ-KQ46944 | Human | 391714 | Details Get a Quote |
| TRIM73 Knockout HCT 116 Cell Line | EDJ-KQ49162 | Human | 375593 | Details Get a Quote |
| TRIM7 Knockout HeLa Cell Line | EDJ-KQ35349 | Human | 81786 | Details Get a Quote |
| TRIM7 Knockout A-549 Cell Line | EDJ-KQ36572 | Human | 81786 | Details Get a Quote |
