TRIM59 Gene - Tripartite Motif Containing 59
A RING finger E3 ubiquitin ligase implicated in cancer and innate immunity
Gene Information Card
| Symbol | TRIM59 |
|---|---|
| Full Name | Tripartite Motif Containing 59 |
| Gene Type | protein-coding |
| Chromosomal Location | 3q25.33 |
| NCBI Gene ID | 286827 ncbi.nlm.nih.gov/gene/286827 |
| Ensembl ID | ENSG00000170836 |
| UniProt ID | Q8IWR1 |
| OMIM ID | 616345 |
| HGNC ID | 30836 |
| Aliases | TRIM59; RNF104; TRIM59A |
Description
TRIM59 (Tripartite Motif Containing 59) is a protein-coding gene located on chromosome 3q25.33. It encodes a member of the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box domains, and a coiled-coil region. TRIM59 functions as an E3 ubiquitin ligase, playing roles in innate immunity, cell proliferation, and apoptosis. It is frequently overexpressed in various cancers, including gastric, lung, and breast cancer, where it promotes tumor progression. Additionally, TRIM59 is involved in the regulation of NF-kB signaling and antiviral responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Overexpression promotes tumor growth and metastasis via NF-kB pathway activation | PMID: 25384966 (COSMIC, NCBI) |
| Lung cancer | Upregulation enhances cell proliferation and invasion; associated with poor prognosis | PMID: 28622376 (COSMIC, NCBI) |
| Breast cancer | High expression correlates with aggressive phenotype and reduced survival | PMID: 29187732 (COSMIC, NCBI) |
| Prostate cancer | Overexpression drives androgen-independent growth | PMID: 26743024 (COSMIC, NCBI) |
| Innate immune response | Regulates antiviral signaling by modulating STING degradation | PMID: 28381568 (UniProt, NCBI) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Spleen | 8.7 | Low |
| Lung | 6.2 | Low |
| Breast | 4.5 | Low |
| Stomach | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung) | 15.2 | High expression; associated with oncogenic role |
| MCF7 (Breast) | 10.4 | Moderate; promotes proliferation |
| HeLa (Cervical) | 8.1 | Moderate |
| HCT116 (Colon) | 6.5 | Low |
| K562 (Leukemia) | 3.2 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.412C>T (p.Arg138Cys) | Missense | 0.5% (COSMIC) | Potential loss of E3 ligase activity |
| c.755A>G (p.Gln252Arg) | Missense | 0.2% (COSMIC) | Unknown; possibly neutral |
| c.1024_1025insA | Frameshift | 0.1% (COSMIC) | Truncated protein; likely loss of function |
| c.1204G>A (p.Glu402Lys) | Missense | 0.3% (ClinVar) | Uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations leading to premature stop codons are likely loss-of-function, impairing ubiquitin ligase activity and downstream signaling.
Gain of Function (GOF)
Missense mutations in the RING domain may enhance E3 ligase activity, potentially increasing oncogenic signaling.
Dominant Negative (DN)
Certain missense mutations could interfere with TRIM59 oligomerization, acting in a dominant-negative manner to disrupt normal function.
View complete mutation data：
Gene Ontology (GO)
| • protein ubiquitination | • innate immune response |
| • regulation of NF-kB signaling | • cell proliferation |
| • apoptosis | • zinc ion binding |
| • ubiquitin-protein transferase activity |
Pathways
• NF-kB signaling pathway
• Innate immune response (RIG-I/MDA5 pathway)
• p53 signaling pathway (regulation)
• Cell cycle regulation
Protein Summary
TRIM59 is a 403-amino acid protein with a RING finger domain, B-box type 1 and 2 domains, and a coiled-coil region. It functions as an E3 ubiquitin ligase, catalyzing the transfer of ubiquitin to target proteins. TRIM59 is known to ubiquitinate STING, leading to its degradation and modulation of antiviral innate immunity. In cancer, TRIM59 promotes tumorigenesis by activating NF-kB signaling and inhibiting p53-mediated apoptosis. It is predominantly localized in the cytoplasm and nucleus, and its expression is regulated by various transcription factors.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM59 Knockout HEK293 Cell Line | EDJ-KQ15124 | Human | 286827 | Details Get a Quote |
| TRIM59 Knockout A-549 Cell Line | EDJ-KQ46929 | Human | 286827 | Details Get a Quote |
| TRIM59 Knockout HCT 116 Cell Line | EDJ-KQ46930 | Human | 286827 | Details Get a Quote |
| TRIM59 Knockout HeLa Cell Line | EDJ-KQ46931 | Human | 286827 | Details Get a Quote |
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