TRIM55: Tripartite Motif Containing 55
A muscle-specific RING finger protein involved in myogenesis and sarcomere assembly.
Gene Information Card
| Symbol | TRIM55 |
|---|---|
| Full Name | Tripartite Motif Containing 55 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q13.1 |
| NCBI Gene ID | 84675 ncbi.nlm.nih.gov/gene/84675 |
| Ensembl ID | ENSG00000164741 |
| UniProt ID | Q9BXU1 |
| OMIM ID | 606469 |
| HGNC ID | 13435 |
| Aliases | MURF-2, MURF2, RNF29, tripartite motif-containing 55 |
Description
TRIM55, also known as MURF-2, encodes a member of the tripartite motif (TRIM) family. The protein contains a RING finger domain, a B-box, and a coiled-coil region. It is predominantly expressed in cardiac and skeletal muscle, where it localizes to the sarcomere and plays a role in myogenesis, sarcomere assembly, and muscle protein turnover. TRIM55 interacts with titin and other sarcomeric proteins, and its expression is regulated during muscle differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cardiomyopathy, dilated | Altered sarcomere integrity due to TRIM55 dysregulation | OMIM #606469; limited case reports |
| Muscular dystrophy | Potential disruption of myogenesis and sarcomere assembly | UniProt Q9BXU1; inferred from functional studies |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 45.2 | High |
| Skeletal muscle | 38.7 | High |
| Testis | 1.2 | Low |
| Lung | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Cardiomyocytes (iPS-derived) | 32.1 | High expression |
| Skeletal muscle myoblasts | 28.4 | Differentiation-dependent |
| HeLa | 0.3 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Pro34Leu) | Missense | <0.01% | Unknown; predicted benign |
| c.457G>A (p.Glu153Lys) | Missense | <0.01% | Unknown; predicted possibly damaging |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ubiquitin-mediated proteolysis (KEGG: hsa04120)
• Sarcomere assembly and maintenance (Reactome: R-HSA-5250913)
Protein Summary
TRIM55 (MURF-2) is a 486-amino acid protein with a molecular weight of approximately 55 kDa. It contains an N-terminal RING finger domain (zinc-binding), a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to the sarcomeric Z-disc and M-line, where it interacts with titin and other muscle proteins. TRIM55 functions as an E3 ubiquitin ligase, targeting proteins for proteasomal degradation, and is essential for proper sarcomere assembly and muscle differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM55 Knockout HEK293 Cell Line | EDJ-KQ3810 | Human | 84675 | Details Get a Quote |
| TRIM55 Knockout HeLa Cell Line | EDJ-KQ57641 | Human | 84675 | Details Get a Quote |
| TRIM55 Knockout A-549 Cell Line | EDJ-KQ66139 | Human | 84675 | Details Get a Quote |
| TRIM55 Knockout HCT 116 Cell Line | EDJ-KQ74566 | Human | 84675 | Details Get a Quote |
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