TRIM52
Tripartite Motif Containing 52
Gene Information Card
| Symbol | TRIM52 |
|---|---|
| Full Name | Tripartite Motif Containing 52 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 84871 ncbi.nlm.nih.gov/gene/84871 |
| Ensembl ID | ENSG00000164172 |
| UniProt ID | Q96A44 |
| OMIM ID | 614544 |
| HGNC ID | 19030 |
| Aliases | RNF102, TRIM52-AS1 |
Description
TRIM52 (Tripartite Motif Containing 52) is a protein-coding gene belonging to the tripartite motif (TRIM) family. The encoded protein contains a RING finger domain, B-box zinc finger, and coiled-coil region, and functions as an E3 ubiquitin ligase involved in innate immune responses, antiviral signaling, and regulation of NF-kappaB pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | TRIM52 overexpression promotes tumor growth via NF-κB activation | PMID: 29367642 |
| Influenza A infection | TRIM52 restricts influenza A virus replication by targeting viral nucleoprotein for ubiquitination | PMID: 31043529 |
| Prostate cancer | TRIM52 upregulation correlates with poor prognosis and promotes cell proliferation | PMID: 31578326 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Spleen | 8.7 | Medium |
| Lung | 6.1 | Low |
| Liver | 4.5 | Low |
| Kidney | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 10.1 | Hepatocellular carcinoma cell line |
| A549 | 7.8 | Lung adenocarcinoma cell line |
| HEK293 | 5.4 | Embryonic kidney cell line |
| K562 | 4.2 | Chronic myeloid leukemia cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | 0.001% (gnomAD) | Unknown functional effect |
| c.101G>A (p.Arg34Gln) | Missense | 0.002% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • zinc ion binding (GO:0008270) |
| • metal ion binding (GO:0046872) | • ubiquitin protein ligase activity (GO:0061630) |
| • innate immune response (GO:0045087) | • positive regulation of NF-kappaB transcription factor activity (GO:0051092) |
Pathways
• RIG-I-like receptor signaling pathway (KEGG: hsa04622)
• NF-kappa B signaling pathway (KEGG: hsa04064)
• Innate Immune System (Reactome: R-HSA-168249)
Protein Summary
TRIM52 is a 324-amino acid protein (UniProt Q96A44) with a molecular weight of approximately 37 kDa. It contains a RING-type zinc finger domain (residues 22-60) that mediates E3 ubiquitin ligase activity, a B-box-type zinc finger (residues 99-141), and a coiled-coil region (residues 142-200). The protein localizes to the cytoplasm and is involved in ubiquitination of viral proteins and host signaling molecules, modulating antiviral responses and cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM52 Knockout HEK293 Cell Line | EDJ-KQ10219 | Human | 84851 | Details Get a Quote |
| TRIM52 Knockout A-549 Cell Line | EDJ-KQ37382 | Human | 84851 | Details Get a Quote |
| TRIM52 Knockout HCT 116 Cell Line | EDJ-KQ37383 | Human | 84851 | Details Get a Quote |
| TRIM52 Knockout HeLa Cell Line | EDJ-KQ37384 | Human | 84851 | Details Get a Quote |
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