TRIM51
Tripartite Motif Containing 51
Gene Information Card
| Symbol | TRIM51 |
|---|---|
| Full Name | Tripartite Motif Containing 51 |
| Gene Type | Protein coding |
| Chromosomal Location | 11p15.4 |
| NCBI Gene ID | 100130894 ncbi.nlm.nih.gov/gene/100130894 |
| Ensembl ID | ENSG00000204103 |
| UniProt ID | A6NHR9 |
| OMIM ID | 616311 |
| HGNC ID | 37274 |
| Aliases | RNF125, TRIM51A |
Description
TRIM51 (tripartite motif containing 51) is a protein-coding gene belonging to the tripartite motif (TRIM) family. The encoded protein contains a RING finger domain, B-box zinc finger, and coiled-coil region, characteristic of TRIM proteins involved in ubiquitination and innate immune signaling. TRIM51 is implicated in antiviral responses and may modulate interferon signaling. Expression is enriched in immune tissues and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect tumor immune surveillance | COSMIC, literature |
| Viral infections | Potential role in ubiquitin-mediated antiviral response | UniProt, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lymph node | 6.7 | Low |
| Bone marrow | 5.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | Moderate expression |
| K562 | 9.8 | Low expression |
| HeLa | 7.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown functional impact |
| c.100C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations may lead to truncated protein and loss of E3 ubiquitin ligase activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • zinc ion binding (GO:0008270) |
| • ubiquitin protein ligase activity (GO:0061630) | • innate immune response (GO:0045087) |
| • cytoplasm (GO:0005737) |
Pathways
• Ubiquitin mediated proteolysis
• RIG-I-like receptor signaling pathway
Protein Summary
TRIM51 is a 493-amino acid protein with a molecular weight of approximately 56 kDa. It contains a RING-type zinc finger domain (residues 15-55) that confers E3 ubiquitin ligase activity, two B-box zinc fingers (residues 90-130 and 140-180), and a coiled-coil region (residues 200-250). The protein localizes to the cytoplasm and is involved in ubiquitination of target proteins, modulating innate immune signaling pathways.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM51 Knockout HEK293 Cell Line | EDJ-KQ10193 | Human | 84767 | Details Get a Quote |
| TRIM51G Knockout HEK293 Cell Line | EDJ-KQ17192 | Human | 120824 | Details Get a Quote |
| TRIM51G Knockout A-549 Cell Line | EDJ-KQ49149 | Human | 120824 | Details Get a Quote |
| TRIM51G Knockout HCT 116 Cell Line | EDJ-KQ49150 | Human | 120824 | Details Get a Quote |
| TRIM51G Knockout HeLa Cell Line | EDJ-KQ49151 | Human | 120824 | Details Get a Quote |
| TRIM51 Knockout HeLa Cell Line | EDJ-KQ57660 | Human | 84767 | Details Get a Quote |
| TRIM51 Knockout A-549 Cell Line | EDJ-KQ66158 | Human | 84767 | Details Get a Quote |
| TRIM51 Knockout HCT 116 Cell Line | EDJ-KQ74584 | Human | 84767 | Details Get a Quote |
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