TRIM13: Tripartite Motif Containing 13
A RING-type E3 ubiquitin ligase involved in endoplasmic reticulum-associated degradation and tumor suppression.
Gene Information Card
| Symbol | TRIM13 |
|---|---|
| Full Name | Tripartite Motif Containing 13 |
| Gene Type | Protein coding |
| Chromosomal Location | 13q14.2 |
| NCBI Gene ID | 10206 ncbi.nlm.nih.gov/gene/10206 |
| Ensembl ID | ENSG00000139618 |
| UniProt ID | O60858 |
| OMIM ID | 606760 |
| HGNC ID | 9977 |
| Aliases | RFP2, LEU5, RNF77 |
Description
TRIM13 (Tripartite Motif Containing 13) encodes a member of the tripartite motif (TRIM) family. The protein contains a RING-type zinc finger, a B-box, and a coiled-coil domain, and functions as an E3 ubiquitin ligase. It localizes to the endoplasmic reticulum (ER) membrane and is involved in ER-associated degradation (ERAD), ubiquitination, and regulation of NF-kappaB signaling. TRIM13 is considered a tumor suppressor gene, frequently deleted or downregulated in B-cell chronic lymphocytic leukemia and multiple myeloma.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| B-cell chronic lymphocytic leukemia | Deletion or epigenetic silencing of TRIM13 on 13q14 contributes to leukemogenesis | PMID: 12460929; COSMIC |
| Multiple myeloma | Loss of TRIM13 expression associated with disease progression and poor prognosis | PMID: 17690171; COSMIC |
| Breast cancer | Reduced TRIM13 expression correlates with tumor aggressiveness | PMID: 25329317 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 8.2 | Medium |
| Lymph node | 6.5 | Medium |
| Spleen | 5.1 | Low |
| Testis | 4.3 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 12.4 | High expression |
| HEK 293 (embryonic kidney) | 7.8 | Moderate expression |
| HeLa (cervical cancer) | 5.2 | Low expression |
| MCF7 (breast cancer) | 3.1 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | 0.01% (gnomAD) | Loss of start codon; predicted loss of function |
| c.337C>T (p.Arg113*) | Nonsense | 0.002% (COSMIC) | Premature truncation; loss of E3 ligase activity |
| c.494_495del (p.Glu165Glyfs*12) | Frameshift | 0.001% (COSMIC) | Frameshift; loss of function |
| c.788G>A (p.Arg263Gln) | Missense | 0.005% (ClinVar) | Uncertain significance; possibly damaging |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg113*, p.Glu165Glyfs*12) abolish E3 ubiquitin ligase activity, impairing ERAD and tumor suppression.
Gain of Function (GOF)
No gain-of-function mutations have been reported for TRIM13.
Dominant Negative (DN)
No dominant-negative mutations have been characterized for TRIM13.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Endoplasmic reticulum-associated degradation (ERAD) pathway
• Ubiquitin-proteasome pathway
• NF-kappaB signaling (negative regulation)
Protein Summary
TRIM13 is a 403-amino acid protein (UniProt O60858) with a molecular weight of ~46 kDa. It contains an N-terminal RING finger domain (residues 24-67) responsible for E3 ubiquitin ligase activity, a B-box domain (residues 95-138), and a coiled-coil region (residues 145-200). The protein is anchored to the ER membrane via a C-terminal transmembrane domain (residues 370-390). TRIM13 mediates ubiquitination of misfolded ER proteins and targets them for proteasomal degradation. It also negatively regulates NF-kappaB activation by promoting ubiquitination of IKKgamma/NEMO.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM13 Knockout HEK293 Cell Line | EDJ-KQ6949 | Human | 10206 | Details Get a Quote |
| TRIM13 Knockout A-549 Cell Line | EDJ-KQ31613 | Human | 10206 | Details Get a Quote |
| TRIM13 Knockout HCT 116 Cell Line | EDJ-KQ31614 | Human | 10206 | Details Get a Quote |
| TRIM13 Knockout HeLa Cell Line | EDJ-KQ31615 | Human | 10206 | Details Get a Quote |
