TRIM10: Tripartite Motif Containing 10
A RING-type E3 ubiquitin ligase involved in immune regulation and hematopoiesis.
Gene Information Card
| Symbol | TRIM10 |
|---|---|
| Full Name | Tripartite Motif Containing 10 |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.3 (MHC class I region) |
| NCBI Gene ID | 10107 ncbi.nlm.nih.gov/gene/10107 |
| Ensembl ID | ENSG00000132122 |
| UniProt ID | Q9UK18 |
| OMIM ID | 605701 |
| HGNC ID | 12307 |
| Aliases | RFB30, HERF1, RNF9 |
Description
TRIM10 (Tripartite Motif Containing 10) is a protein-coding gene located in the major histocompatibility complex (MHC) class I region on chromosome 6p21.3. It encodes a member of the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc fingers, and a coiled-coil region. TRIM10 functions as an E3 ubiquitin ligase, playing roles in innate immunity, hematopoietic differentiation, and protein ubiquitination. Alternative splicing generates multiple transcript variants.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hereditary Hemochromatosis (modifier) | TRIM10 variants may influence iron metabolism through MHC-linked loci; exact mechanism unclear. | PMID: 15654339 |
| Autoimmune diseases (e.g., rheumatoid arthritis) | Located in MHC region; polymorphisms associated with susceptibility. | GWAS catalog (NHGRI-EBI) |
| Cancer (hematologic malignancies) | Dysregulation of TRIM10 expression observed in leukemia; potential role in cell differentiation. | COSMIC v99 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lymph node | 6.1 | Low |
| Testis | 4.7 | Low |
| Lung | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 (leukemia) | 15.2 | Highest expression among cancer lines |
| HL-60 (promyeloblast) | 10.8 | High |
| HeLa (cervical) | 1.5 | Low |
| A549 (lung) | 0.9 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.472C>T (p.Arg158Cys) | Missense | <0.01% (gnomAD) | Unknown; located in B-box domain |
| c.1018G>A (p.Gly340Ser) | Missense | 0.02% (gnomAD) | Unknown; located in coiled-coil region |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar.
Gain of Function (GOF)
Not described.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • zinc ion binding (GO:0008270) |
| • protein ubiquitination (GO:0016567) | • identical protein binding (GO:0042800) |
| • ubiquitin protein ligase activity (GO:0061630) |
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• Innate immune system (Reactome: R-HSA-168249)
Protein Summary
TRIM10 is a 541-amino acid protein with a molecular weight of approximately 61 kDa. It contains an N-terminal RING finger domain (required for E3 ligase activity), two B-box zinc fingers, and a coiled-coil region. The protein localizes to the cytoplasm and nucleus. TRIM10 mediates ubiquitination of target proteins, influencing cell proliferation and differentiation, particularly in hematopoietic lineages.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM10 Knockout HEK293 Cell Line | EDJ-KQ6899 | Human | 10107 | Details Get a Quote |
| TRIM10 Knockout HCT 116 Cell Line | EDJ-KQ31518 | Human | 10107 | Details Get a Quote |
| TRIM10 Knockout HeLa Cell Line | EDJ-KQ55319 | Human | 10107 | Details Get a Quote |
| TRIM10 Knockout A-549 Cell Line | EDJ-KQ63803 | Human | 10107 | Details Get a Quote |
